ID   CHS7_SORBI              Reviewed;         400 AA.
AC   Q9XGX1;
DT   08-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Chalcone synthase 7;
DE            EC=2.3.1.74;
DE   AltName: Full=Naringenin-chalcone synthase 7;
GN   Name=CHS7;
OS   Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX   NCBI_TaxID=4558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. BTx623;
RA   Lo S.-C.C., Nicholson R.L.;
RT   "Molecular cloning of chalcone synthase genes from sorghum.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC       tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC       which can under specific conditions spontaneously isomerize into
CC       naringenin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC         tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; AF152554; AAD41879.1; -; Genomic_DNA.
DR   RefSeq; XP_002450876.1; XM_002450831.1.
DR   AlphaFoldDB; Q9XGX1; -.
DR   SMR; Q9XGX1; -.
DR   STRING; 4558.Sb05g020220.1; -.
DR   EnsemblPlants; EES09864; EES09864; SORBI_3005G137200.
DR   GeneID; 8064819; -.
DR   Gramene; EES09864; EES09864; SORBI_3005G137200.
DR   KEGG; sbi:8064819; -.
DR   eggNOG; ENOG502QRSY; Eukaryota.
DR   HOGENOM; CLU_034992_2_0_1; -.
DR   OrthoDB; 950070at2759; -.
DR   UniPathway; UPA00154; -.
DR   ExpressionAtlas; Q9XGX1; baseline and differential.
DR   GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Flavonoid biosynthesis; Transferase.
FT   CHAIN           1..400
FT                   /note="Chalcone synthase 7"
FT                   /id="PRO_0000216061"
FT   ACT_SITE        168
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   400 AA;  43576 MW;  7A67C8D6ADA05CB9 CRC64;
     MAGATVTVEE VRKAQRATGP ATVLAIGTAT PANCVHQADY PDYYFRITKS EHMTDLKEKF
     KRMCDKSQIR KRYMHLTEEY LAENPNMCAY MAPSLDARQD IVVVEVPKLG KAAAQKAIKE
     WGQPKSKITH LVFCTTSGVD MPGADYQLTK MLGLRPSVNR LMMYQQGCFA GGTVLRVAKD
     LAENNRGARV LVVCSEITAV TFRGPSESHL DSMVGQALFG DGAAAVIVGA DPDKRVECPL
     FQLVSASQTI LPDSEGAIDG HLREVGLTFH LLKDVPGLIS KNIERSLEEA FKPLGITDYN
     SIFWVAHPGG PAILDQVEAK VGLKKERMRA TRHVLSEYGN MSSACVLFIL DEMRKRSAEE
     GQATTGEGFD WGVLFGFGPG LTVETVVLHS VPITIAAITA