CHSA_IPOTR
ID CHSA_IPOTR Reviewed; 362 AA.
AC P48403;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Chalcone synthase A;
DE EC=2.3.1.74;
DE AltName: Full=Naringenin-chalcone synthase A;
DE Short=CHS-A;
DE Flags: Fragment;
GN Name=CHSA;
OS Ipomoea triloba (Trilobed morning glory).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Convolvulaceae; Ipomoeeae; Ipomoea.
OX NCBI_TaxID=35885;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7724563; DOI=10.1073/pnas.92.8.3338;
RA Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.;
RT "Evolution of the chalcone synthase gene family in the genus Ipomoea.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995).
CC -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC which can under specific conditions spontaneously isomerize into
CC naringenin.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000305}.
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DR EMBL; U15952; AAC49034.1; -; Genomic_DNA.
DR AlphaFoldDB; P48403; -.
DR SMR; P48403; -.
DR UniPathway; UPA00154; -.
DR GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; PTHR11877; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; SSF53901; 2.
DR PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Flavonoid biosynthesis; Transferase.
FT CHAIN 1..>362
FT /note="Chalcone synthase A"
FT /id="PRO_0000215999"
FT ACT_SITE 168
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
FT NON_TER 362
SQ SEQUENCE 362 AA; 40472 MW; FC275F289E8707EC CRC64;
MSPTVTVQLT DDTAKRFEGH AKLLAIGTAT PTNWVDQATY PDFYFRITNS ERLLEHKEKF
RRICNKSKIR FRHLVLTEEL LKKSPNLCTY NDASLNTRQD ILVSEVPKLG KEAAMKAIKE
WGRPISEITH LVFCTTSGVD MPGADFQLTK LLGLNSSVKR LMMYQQGCNA GAAMLRLVKD
LAENNKGARV LVVCSEITIN IFRGPSLEQD DNLLAQCLFG DGSAAMIVGK DPRPGLETPL
FELVSSAQTI VPNTDSHLKL TLREMGLTFH CSRAVPSVLA ENVEDCLVKA FEPYGISDWN
SIFWVFHPGG YAIVDRVEER LGLGPERLRA SRDVLSEYGN LTSACVLFIL DEMRKKSKKD
EQ