ID   CHSA_SOLTU              Reviewed;         389 AA.
AC   Q41436;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Chalcone synthase 1A;
DE            EC=2.3.1.74;
DE   AltName: Full=Naringenin-chalcone synthase 1A;
GN   Name=CHS1A;
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Red Pontiac;
RA   Jeon J.-H., Kim H.-S., Choi K.-H., Joung Y.-H., Joung H., Byun S.-M.;
RT   "Characterization of two members of the chalcone synthase gene family from
RT   Solanum tuberosum L.";
RL   (er) Plant Gene Register PGR96-027(1996).
CC   -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC       tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC       which can under specific conditions spontaneously isomerize into
CC       naringenin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC         tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; U47739; AAB67734.1; -; mRNA.
DR   RefSeq; NP_001275352.1; NM_001288423.1.
DR   AlphaFoldDB; Q41436; -.
DR   SMR; Q41436; -.
DR   GeneID; 102577871; -.
DR   KEGG; sot:102577871; -.
DR   InParanoid; Q41436; -.
DR   OrthoDB; 950070at2759; -.
DR   UniPathway; UPA00154; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; Q41436; baseline and differential.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IBA:GO_Central.
DR   GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030639; P:polyketide biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Flavonoid biosynthesis; Reference proteome; Transferase.
FT   CHAIN           1..389
FT                   /note="Chalcone synthase 1A"
FT                   /id="PRO_0000216052"
FT   ACT_SITE        164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   389 AA;  42562 MW;  B181D9C6B9170A34 CRC64;
     MVTVEEYRKA QRAEGPATIL AIGTSTPSNC VDQSTYPDYY FRITNSEHKT ELKEKFKRMC
     DKSMIKKRYM HLTEEILKEN PNMCAYMAPS LDARQDIVVV EVPKLGKEAA QKAIKEWGQP
     KSKITHLVFC TTSGVDMPGC DYQLAKLLGL RPSVKRLMMY QQGCFVGGTV LRLAKDLAEN
     NKGARVLVVC SEITAVTFRG PSESHLDSLV GQALFGDGAA AIIMGSDPII GVERPLFELV
     SAAQTLVPDS EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLLEAFQPL GISDWNSLFW
     IAHPGGPAIL DQVELKLGLK QEKLRATREV LSNYGNMSSA CVLFILDEMR KASTNEGLGT
     TGEGLEWGVL FGFGPGLTVE TVVLHSVAT