ID   CHSB_SOLTU              Reviewed;         389 AA.
AC   Q43163;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Chalcone synthase 1B;
DE            EC=2.3.1.74;
DE   AltName: Full=Naringenin-chalcone synthase 1B;
GN   Name=CHS1B;
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Red Pontiac;
RA   Jeon J.-H., Kim H.-S., Choi K.-H., Joung Y.-H., Joung H., Byun S.-M.;
RT   "Characterization of two members of the chalcone synthase gene family from
RT   Solanum tuberosum L.";
RL   (er) Plant Gene Register PGR96-027(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DM1-3 516 R44;
RX   PubMed=21743474; DOI=10.1038/nature10158;
RG   The Potato Genome Sequencing Consortium;
RT   "Genome sequence and analysis of the tuber crop potato.";
RL   Nature 475:189-195(2011).
CC   -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC       tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC       which can under specific conditions spontaneously isomerize into
CC       naringenin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC         tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; U47740; AAB67735.1; -; mRNA.
DR   AlphaFoldDB; Q43163; -.
DR   SMR; Q43163; -.
DR   STRING; 4113.PGSC0003DMT400076178; -.
DR   EnsemblPlants; PGSC0003DMT400076178; PGSC0003DMT400076178; PGSC0003DMG400029620.
DR   Gramene; PGSC0003DMT400076178; PGSC0003DMT400076178; PGSC0003DMG400029620.
DR   eggNOG; ENOG502QRSY; Eukaryota.
DR   HOGENOM; CLU_034992_2_0_1; -.
DR   InParanoid; Q43163; -.
DR   OMA; ANICKKS; -.
DR   UniPathway; UPA00154; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; Q43163; baseline and differential.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IBA:GO_Central.
DR   GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030639; P:polyketide biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Flavonoid biosynthesis; Reference proteome; Transferase.
FT   CHAIN           1..389
FT                   /note="Chalcone synthase 1B"
FT                   /id="PRO_0000216053"
FT   ACT_SITE        164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   389 AA;  42548 MW;  E7334A1A34D8D1CC CRC64;
     MVTVEEYRKA QRAEGPATIL AIGTSTPSNC VDQSTYPDYY FRITNSEHKT ELKEKFKRMC
     DKSMIKKRYM HLTEEILKEN PNMCAYMAPS LDARQDIVVV EVPKLGKEAA QKAIKEWGQP
     KSKITHLVFC TTSGVDMPGC DYQLAKLLGL RPSVKRLMMY QQGCFAGGTV LRLAKDLAEN
     NKGARVLVVC SEITAVTFRG PSESHLDSLV GQALFGDGAA AIIMGSDPII GVERPLFELV
     SAAQTLVPDS EGAIDGHLRE VGLTFHLLKD VPGLISKNIE KSLLEAFQPL GISDWNSLFW
     IAHPGGPAIL DQVELKLGLK QEKLRATREV LSNYGNMSSA CVLFILDEMR KASTKEGLGT
     TGEGLEWGVL FGFGPGLTVE TVVLHSVAT