ID   CHSD_IPONI              Reviewed;         388 AA.
AC   O22045;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Chalcone synthase D;
DE            EC=2.3.1.74;
DE   AltName: Full=Naringenin-chalcone synthase D;
DE            Short=CHS-D;
GN   Name=CHSD;
OS   Ipomoea nil (Japanese morning glory) (Pharbitis nil).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Convolvulaceae; Ipomoeeae; Ipomoea.
OX   NCBI_TaxID=35883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. KK/ZSK-2; TISSUE=Flower bud;
RX   PubMed=9249990; DOI=10.1093/oxfordjournals.pcp.a029232;
RA   Fukada-Tanaka S., Hoshino A., Hisatomi Y., Habu Y., Hasebe M., Iida S.;
RT   "Identification of new chalcone synthase genes for flower pigmentation in
RT   the Japanese and common morning glories.";
RL   Plant Cell Physiol. 38:754-758(1997).
CC   -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC       tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC       which can under specific conditions spontaneously isomerize into
CC       naringenin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC         tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB001818; BAA21787.1; -; mRNA.
DR   RefSeq; XP_019181556.1; XM_019326011.1.
DR   AlphaFoldDB; O22045; -.
DR   SMR; O22045; -.
DR   GeneID; 109176547; -.
DR   KEGG; ini:109176547; -.
DR   OrthoDB; 950070at2759; -.
DR   UniPathway; UPA00154; -.
DR   GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Flavonoid biosynthesis; Transferase.
FT   CHAIN           1..388
FT                   /note="Chalcone synthase D"
FT                   /id="PRO_0000216037"
FT   ACT_SITE        164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   388 AA;  42183 MW;  1BE2CDB2C2DABDEE CRC64;
     MVTVEEVRKA QRAEGPATIL AIGTATPANC VDQSTYPDYY FRITNSDHMT DLKQKFQRMC
     DKSMITKRYM HLTEEILKEN PSFCEYMAPS LDARQDIVVV EVPKLGKEAA QSAIKEWGQP
     KSKITHVIFC TTSGVDMPGA DYQLTKLLGL RPSVKRLMMY QQGCFAGGTV LRVAKDLAEN
     NKAARVLVVC SEITVVTFRG PNETHLDSLV GQALFGDGAA AIIVGSDPTP AEKPLFQLVS
     AAQTLAPDSC GAIDGHLREV GLTFHLLKDV PSIVSNNIEK CLSEAFNPLG ISDWNSIFWI
     AHPGGPAILD QVEDKLGLKP EKLRATRHVL SEYGNMSSAC VLFILDEMRK ASSNDGLGTT
     GEGLEWGVLF GFGPGLTIET VVLHSVPA