ID   CHSD_PETHY              Reviewed;         419 AA.
AC   P22925;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Chalcone synthase D;
DE            EC=2.3.1.74;
DE   AltName: Full=Naringenin-chalcone synthase D;
GN   Name=CHSD;
OS   Petunia hybrida (Petunia).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Petunioideae; Petunia.
OX   NCBI_TaxID=4102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Violet 30; TISSUE=Leaf;
RX   PubMed=2806915; DOI=10.1016/0378-1119(89)90185-6;
RA   Koes R.E., Spelt C.E., van den Elzen P.J.M., Mol J.N.M.;
RT   "Cloning and molecular characterization of the chalcone synthase multigene
RT   family of Petunia hybrida.";
RL   Gene 81:245-257(1989).
CC   -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC       tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC       which can under specific conditions spontaneously isomerize into
CC       naringenin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC         tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; X14593; CAA32733.1; -; Genomic_DNA.
DR   PIR; A72821; SYPJCD.
DR   AlphaFoldDB; P22925; -.
DR   SMR; P22925; -.
DR   UniPathway; UPA00154; -.
DR   GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Flavonoid biosynthesis; Transferase.
FT   CHAIN           1..419
FT                   /note="Chalcone synthase D"
FT                   /id="PRO_0000216031"
FT   ACT_SITE        164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   419 AA;  45979 MW;  55827338DC812ACD CRC64;
     MVTVEEVRNA QRAEGPATVL AIGTATPSNC VDQSTYPDYY FRITDSEHKT ELKEKFKRIC
     DKSMIKKRYM HLTEKILKEN PNICESMAPS LDARTNIYAV EVPKLGKEAA EKAIEEWNQP
     KSRITHLVFC TTTGVSMPGA DFQLTKLLGL GSSVKRFMMN QLGCFAGGTV LRLAKDLAEN
     NKGARVLVVC SEITVVTFRG PNDTHFDSLV GQALFGDGAA AVIIGSDPIP NVERPLFELV
     SAAQTLLPDS KNSICGELRE IGLTFHLLKD VAELISNNIE KSLVEVFQPL GISAWNSIFW
     VAHPGGPAIL NQVELKLGLN PEKLGATRHV LSEYGNMSSA SILFVLDEMR KSSTQKGFDT
     TGEGLKWGVL IGFGPGITFE TIVLHSVSTQ GSFGIRDWDY NFGIEFKIIF IPYLVLGIS