ID   CHSG_PETHY              Reviewed;         393 AA.
AC   P22927;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 2.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Chalcone synthase G;
DE            EC=2.3.1.74;
DE   AltName: Full=Naringenin-chalcone synthase G;
GN   Name=CHSG;
OS   Petunia hybrida (Petunia).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Petunioideae; Petunia.
OX   NCBI_TaxID=4102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Violet 30; TISSUE=Leaf;
RX   PubMed=2806915; DOI=10.1016/0378-1119(89)90185-6;
RA   Koes R.E., Spelt C.E., van den Elzen P.J.M., Mol J.N.M.;
RT   "Cloning and molecular characterization of the chalcone synthase multigene
RT   family of Petunia hybrida.";
RL   Gene 81:245-257(1989).
CC   -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC       tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC       which can under specific conditions spontaneously isomerize into
CC       naringenin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC         tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC   -!- TISSUE SPECIFICITY: Expressed in seedlings after illumination with UV
CC       light. No expression detectable in flowers. It is not known for sure
CC       whether CHSG encodes a chalcone synthase or a very closely related
CC       condensing enzyme.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; X14595; CAA32735.1; -; Genomic_DNA.
DR   PIR; C72821; SYPJCG.
DR   AlphaFoldDB; P22927; -.
DR   SMR; P22927; -.
DR   PRIDE; P22927; -.
DR   UniPathway; UPA00154; -.
DR   GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Flavonoid biosynthesis; Transferase.
FT   CHAIN           1..393
FT                   /note="Chalcone synthase G"
FT                   /id="PRO_0000216033"
FT   ACT_SITE        164
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   393 AA;  42828 MW;  575E56627EFC18D8 CRC64;
     MATVEEIRKA QRAEGPATVL AIGTANPSNC VDQSAYPDFL FRITTSDHKT ELKEKFKHMC
     EGSMIKKRYL HLTEEILKNN PNICEHKAPS LNARQEIAVA EAPKLGKRAA QKAIEEWSQS
     KSKITHLVFC TTTSVELPGA DYQLTKLLGL SPSVKRSMMY QQGCYGGGTA LRLAKDLAEN
     NKGARVLVVC VEITVMSFQA PSRNDTDELD VLVGQALFAD GASAVIIGSD PILAIEKPLF
     ELVFATQTLI PDSGHVICAN LTEAGLIPHL LKDAPIVISQ NIERRLVEVF KPLGISDWNS
     IFWVAHPGGP AILNQIELKL GLKPEKLRAA RHVLSEYGNM SSACVLFVLD EMRKGTIEKG
     MGTTGEGLEW GLLFGFGPGL TIETVVLHSV SIN