ID   CHSL1_CANSA             Reviewed;         392 AA.
AC   C6KI62;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Chalcone synthase-like protein 1;
DE            EC=2.3.1.-;
GN   Name=CAN383;
OS   Cannabis sativa (Hemp) (Marijuana).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Cannabaceae; Cannabis.
OX   NCBI_TaxID=3483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=19581347; DOI=10.1093/jxb/erp210;
RA   Marks M.D., Tian L., Wenger J.P., Omburo S.N., Soto-Fuentes W., He J.,
RA   Gang D.R., Weiblen G.D., Dixon R.A.;
RT   "Identification of candidate genes affecting Delta9-tetrahydrocannabinol
RT   biosynthesis in Cannabis sativa.";
RL   J. Exp. Bot. 60:3715-3726(2009).
CC   -!- FUNCTION: Chalcone synthase that may use malonyl-CoA and hexanoyl-CoA
CC       as substrates but without producing olivetol or olivetolic acid.
CC       {ECO:0000269|PubMed:19581347}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed at the same level in leaves and in
CC       glandular trichomes. {ECO:0000269|PubMed:19581347}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; GQ222379; ACT10338.1; -; mRNA.
DR   AlphaFoldDB; C6KI62; -.
DR   SMR; C6KI62; -.
DR   PRIDE; C6KI62; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Cytoplasm; Transferase.
FT   CHAIN           1..392
FT                   /note="Chalcone synthase-like protein 1"
FT                   /id="PRO_0000421154"
FT   ACT_SITE        166
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   392 AA;  43175 MW;  5F93F709224C084E CRC64;
     MASISVDQIR KAQRANGPAT VLAIGTANPP TSFYQADYPD FYFRVTKNQH MTELKDKFKR
     ICEKTTIKKR HLYLTEDRLN QHPNLLEYMA PSLNTRQDML VVEIPKLGKE AAMKAIKEWG
     QPKSRITHLI FCSTNGVDMP GADYECAKLL GLSSSVKRVM LYQQGCHAGG SVLRIAKDLA
     ENNKGARILT INSEITIGIF HSPDETYFDG MVGQALFGDG ASATIVGADP DKEIGERPVF
     EMVSAAQEFI PNSDGAVDGH LTEAGLVYHI HKDVPGLISK NIEKSLVEAL NPIGISDWNS
     LFWIVHPGGP AILNAVEAKL HLKKEKMADT RHVLSEYGNM SSVSIFFIMD KLRKRSLEEG
     KSTTGDGFEW GVLFGFGPGL TVETIVLHSL AN