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CHSY_EQUAR
ID   CHSY_EQUAR              Reviewed;         405 AA.
AC   Q9MBB1;
DT   08-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Chalcone synthase;
DE            EC=2.3.1.74;
DE   AltName: Full=Naringenin-chalcone synthase;
GN   Name=CHS;
OS   Equisetum arvense (Field horsetail) (Common horsetail).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Polypodiopsida; Equisetidae; Equisetales; Equisetaceae; Equisetum.
OX   NCBI_TaxID=3258;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yamazaki Y., Sankawa U.;
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC       tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC       which can under specific conditions spontaneously isomerize into
CC       naringenin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-
CC         tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; AB030004; BAA89501.1; -; mRNA.
DR   PDB; 6DX9; X-ray; 1.50 A; A/B=1-405.
DR   PDBsum; 6DX9; -.
DR   AlphaFoldDB; Q9MBB1; -.
DR   SMR; Q9MBB1; -.
DR   PRIDE; Q9MBB1; -.
DR   UniPathway; UPA00154; -.
DR   GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acyltransferase; Flavonoid biosynthesis; Transferase.
FT   CHAIN           1..405
FT                   /note="Chalcone synthase"
FT                   /id="PRO_0000215975"
FT   ACT_SITE        170
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
FT   STRAND          24..31
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          34..38
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           39..41
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           42..49
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           56..67
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          72..77
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           80..85
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           87..89
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          91..93
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           97..123
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           127..129
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          132..139
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           146..154
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          161..167
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           172..185
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          191..198
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   TURN            201..203
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           212..220
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          224..233
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          242..251
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          258..264
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          267..271
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           276..295
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           297..299
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           302..304
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           309..311
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          312..316
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           321..331
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   TURN            335..338
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           339..348
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           352..354
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   HELIX           355..369
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   TURN            375..378
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          380..388
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   TURN            389..391
FT                   /evidence="ECO:0007829|PDB:6DX9"
FT   STRAND          392..400
FT                   /evidence="ECO:0007829|PDB:6DX9"
SQ   SEQUENCE   405 AA;  44216 MW;  F20F5701381813A5 CRC64;
     MTVLEESADA SSRRLAQRAN GPATVLAIGT ANPANVFEQS SYPDFYFDIT NSQHMTELKL
     KFSRMCQKSG IKKRYMHLNS EILKANPSLC AYWEKSLDVR QDIAVVEVPK LGKEASLKAI
     KEWGQPKSKI THLVFCTTSG VDMPGADWAL TKLLGLRPSV KRLMMYQQGC FAGGTVLRVA
     KDVAENNKGA RVLVVCSEIT CVTFRGPSET HLDSLVGQAL FGDGAAAVIL GSDPLPEENP
     CFELHWSGSN ILPDSDGAID GHLREVGLTF HLMKDVPGII SKNIGKVLND AFRSAFDESG
     NAEDRPASVN DIFWIAHPGG PAILDQVEEK MKLAPEKMRA TRDVLSEYGN MSSACVLFIM
     DHMRRMSAQN KLQTTGEGLD WGVLLGFGPG LTVETVLLKS IRLAC
 
 
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