ID   CHS_SAPMO               Reviewed;         886 AA.
AC   P48017;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Chitin synthase;
DE            EC=2.4.1.16;
DE   AltName: Full=Chitin-UDP acetyl-glucosaminyl transferase;
GN   Name=CHS;
OS   Saprolegnia monoica.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC   Saprolegnia.
OX   NCBI_TaxID=37553;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Mort-Bontemps F.;
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role in cell wall biogenesis.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-
CC         D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) +
CC         UDP; Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:58223; EC=2.4.1.16;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the chitin synthase family. {ECO:0000305}.
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DR   EMBL; U19946; AAC49743.1; -; Genomic_DNA.
DR   AlphaFoldDB; P48017; -.
DR   CAZy; GT2; Glycosyltransferase Family 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004100; F:chitin synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0006031; P:chitin biosynthetic process; IEA:InterPro.
DR   InterPro; IPR004835; Chitin_synth.
DR   InterPro; IPR004834; Chitin_synth_fun.
DR   InterPro; IPR013616; Chitin_synth_N.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR22914; PTHR22914; 1.
DR   Pfam; PF01644; Chitin_synth_1; 1.
DR   Pfam; PF08407; Chitin_synth_1N; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell wall biogenesis/degradation; Glycosyltransferase;
KW   Membrane; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..886
FT                   /note="Chitin synthase"
FT                   /id="PRO_0000193714"
FT   TRANSMEM        534..554
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        578..598
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        605..625
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        636..656
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        672..692
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        695..715
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          16..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   886 AA;  98570 MW;  74E347C4B941FE0C CRC64;
     MSDQLDLAAR LRALREGNAA PADPETATHT AWPAPQYHPH CRRCIHKSRS SWEGRMPRAA
     PCAEAEGSYS QVPVWKDSKE TRRSYLDDEP TPQPQSLINM ANTLVQRQRR INLPAAAYSE
     LPTAAQHRRG ASGRQANTAT QVLQLTCTWT LARRSSKSAE ELGTWMNTVA EEARKAALPP
     QLKIARTNVP TVEQAWKGRT PPFHDADEFR LMRYTAVATK DPIQFSNDGY VLRVHQLHRR
     IKVFITITMY NEEGSEILGT LTGLAKGLGY MCKEYGQDFW QEVAVAIVSD GRTKASKTCL
     EYLNGLGAFD EEIMTVTSLG VDTPAGENQT FENYFPPLQV IYALKENNGG KLNSHLWFFN
     AFSEQLNPKY TVLVDVGTIP AETSVFRLIR SMERNYQIGG VAGEIAVEAP NYFNPVIAAQ
     HFEYKISNIM DKSLESVFGF ISVLPGAFSA YRYEAIRAVK GVGPLPEYFK SLTSTTKELG
     PFQGNMYLAE DRILCFELLA RKHKQWTMHY VKDAIARTDV PETLVDLIKQ ARRWLNGSFF
     AGLFAIGTLA VWSQSSHTMS RKLVFTFQFF YLALQNLLSW FLLSNLFLTF YFVLTLAFTD
     SAPALLQAML TLYLAIVGGL IVFALGNKPE PRTASFYLFS CLYMGIIMML VTGISIYGLV
     GKGTSAVKDP RVITGPLATV LSLKGSLSVV SSPRLGLIFL SAFVHGEFSI LLSVIQYFFM
     LPTFVQFAHL SWGTKGLESG GRHGPTKTGG GKVKEVVEQQ KKLEAQRQAA AKEKEDVDNS
     FRAFRSTLLA VVAHDQRHLA LRCDGLHVER VLLEGPQLVV GFFNVIVSRA ALYLLSCASL
     SYSALTAVQW GPPTIPMSAT CRPTGRLITM YRTKATVGLW LPVQRA