CHUR_BOVIN
ID CHUR_BOVIN Reviewed; 112 AA.
AC Q2HJG7;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Protein Churchill;
GN Name=CHURC1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional activator that mediates FGF signaling during
CC neural development (By similarity). Plays a role in the regulation of
CC cell movement (By similarity). Does not bind DNA by itself (By
CC similarity). {ECO:0000250|UniProtKB:Q5U3N7,
CC ECO:0000250|UniProtKB:Q8WUH1, ECO:0000250|UniProtKB:Q9DFZ3}.
CC -!- SIMILARITY: Belongs to the Churchill family. {ECO:0000305}.
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DR EMBL; BC105418; AAI05419.1; -; mRNA.
DR EMBL; EH132529; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001040046.1; NM_001046581.2.
DR AlphaFoldDB; Q2HJG7; -.
DR STRING; 9913.ENSBTAP00000035640; -.
DR PaxDb; Q2HJG7; -.
DR PRIDE; Q2HJG7; -.
DR GeneID; 616539; -.
DR KEGG; bta:616539; -.
DR CTD; 91612; -.
DR VEuPathDB; HostDB:ENSBTAG00000003469; -.
DR eggNOG; ENOG502S4AE; Eukaryota.
DR HOGENOM; CLU_142022_0_0_1; -.
DR InParanoid; Q2HJG7; -.
DR OMA; GTICLEN; -.
DR OrthoDB; 1386726at2759; -.
DR TreeFam; TF333004; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000003469; Expressed in oocyte and 109 other tissues.
DR ExpressionAtlas; Q2HJG7; baseline and differential.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 2.60.40.4240; -; 1.
DR InterPro; IPR038543; Churchill_sf.
DR InterPro; IPR009508; Transcrpt_activator_Churchill.
DR PANTHER; PTHR31931; PTHR31931; 1.
DR Pfam; PF06573; Churchill; 1.
PE 3: Inferred from homology;
KW Activator; Developmental protein; Metal-binding; Reference proteome;
KW Transcription; Transcription regulation; Zinc.
FT CHAIN 1..112
FT /note="Protein Churchill"
FT /id="PRO_0000351551"
FT BINDING 2
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 5
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 30
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 30
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 33
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 59
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 61
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 64
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 66
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 71
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 88
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 91
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
SQ SEQUENCE 112 AA; 12941 MW; 37417661D88B3780 CRC64;
MCVDCVEKEY PNRGNICLES GSFLLNFTGC AVCNKRDFML ITNKSLKEED GEEIVTYDHL
CKNCHHVIAR HEYTFSIMDE FQEYTMLCLL CGKAEDTISI LPDDPRQMTL LF
