CHUR_CHICK
ID CHUR_CHICK Reviewed; 112 AA.
AC Q9DFZ3;
DT 30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Protein Churchill;
GN Name=CHURC1; Synonyms=CHCH;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=14651851; DOI=10.1016/s0092-8674(03)00927-9;
RA Sheng G., dos Reis M., Stern C.D.;
RT "Churchill, a zinc finger transcriptional activator, regulates the
RT transition between gastrulation and neurulation.";
RL Cell 115:603-613(2003).
CC -!- FUNCTION: Transcriptional activator that mediates FGF signaling during
CC neural development (PubMed:14651851). Plays a role in the regulation of
CC cell movement (By similarity). Does not bind DNA by itself (By
CC similarity). {ECO:0000250|UniProtKB:Q5U3N7,
CC ECO:0000250|UniProtKB:Q8WUH1, ECO:0000269|PubMed:14651851}.
CC -!- SIMILARITY: Belongs to the Churchill family. {ECO:0000305}.
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DR EMBL; AF238863; AAG09760.1; -; mRNA.
DR RefSeq; NP_990040.1; NM_204709.1.
DR AlphaFoldDB; Q9DFZ3; -.
DR SMR; Q9DFZ3; -.
DR Ensembl; ENSGALT00000080725; ENSGALP00000057726; ENSGALG00000042309.
DR GeneID; 395448; -.
DR KEGG; gga:395448; -.
DR CTD; 91612; -.
DR VEuPathDB; HostDB:geneid_395448; -.
DR eggNOG; ENOG502TB4E; Eukaryota.
DR GeneTree; ENSGT00390000011163; -.
DR InParanoid; Q9DFZ3; -.
DR OMA; GTICLEN; -.
DR OrthoDB; 1549523at2759; -.
DR PhylomeDB; Q9DFZ3; -.
DR PRO; PR:Q9DFZ3; -.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000042309; Expressed in cerebellum and 13 other tissues.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 2.60.40.4240; -; 1.
DR InterPro; IPR038543; Churchill_sf.
DR InterPro; IPR009508; Transcrpt_activator_Churchill.
DR PANTHER; PTHR31931; PTHR31931; 1.
DR Pfam; PF06573; Churchill; 1.
PE 3: Inferred from homology;
KW Activator; Developmental protein; Metal-binding; Reference proteome;
KW Transcription; Transcription regulation; Zinc.
FT CHAIN 1..112
FT /note="Protein Churchill"
FT /id="PRO_0000089664"
FT BINDING 2
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 5
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 30
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 30
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 33
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 59
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 61
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 64
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 66
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 71
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 88
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 91
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
SQ SEQUENCE 112 AA; 12496 MW; 11AD0115F64A3400 CRC64;
MCGGCVGTEY PERGTTCLEG GSFLLNFVGC ARCGRRDFVL LGNRAAGLHG DDEIITYDHL
CKNCHHLIAR HEYTFSVVDD YQEYTMLCLL CGRAEDSVSI LPDDPRQMTP LF
