CHUR_MOUSE
ID CHUR_MOUSE Reviewed; 112 AA.
AC Q6DG52; Q8VCP1;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Protein Churchill;
GN Name=Churc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcriptional activator that mediates FGF signaling during
CC neural development (By similarity). Plays a role in the regulation of
CC cell movement (By similarity). Does not bind DNA by itself (By
CC similarity). {ECO:0000250|UniProtKB:Q5U3N7,
CC ECO:0000250|UniProtKB:Q8WUH1, ECO:0000250|UniProtKB:Q9DFZ3}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6DG52-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6DG52-2; Sequence=VSP_013378, VSP_013379;
CC -!- SIMILARITY: Belongs to the Churchill family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC019472; AAH19472.1; -; mRNA.
DR EMBL; BC076499; AAH76499.1; -; mRNA.
DR CCDS; CCDS36478.1; -. [Q6DG52-1]
DR RefSeq; NP_996257.1; NM_206534.1. [Q6DG52-1]
DR AlphaFoldDB; Q6DG52; -.
DR SMR; Q6DG52; -.
DR STRING; 10090.ENSMUSP00000047015; -.
DR PhosphoSitePlus; Q6DG52; -.
DR EPD; Q6DG52; -.
DR MaxQB; Q6DG52; -.
DR PaxDb; Q6DG52; -.
DR PeptideAtlas; Q6DG52; -.
DR PRIDE; Q6DG52; -.
DR ProteomicsDB; 279077; -. [Q6DG52-1]
DR ProteomicsDB; 279078; -. [Q6DG52-2]
DR Antibodypedia; 51632; 60 antibodies from 19 providers.
DR Ensembl; ENSMUST00000041262; ENSMUSP00000047015; ENSMUSG00000090258. [Q6DG52-1]
DR Ensembl; ENSMUST00000110399; ENSMUSP00000106029; ENSMUSG00000090258. [Q6DG52-2]
DR GeneID; 211151; -.
DR KEGG; mmu:211151; -.
DR UCSC; uc007nyq.1; mouse. [Q6DG52-1]
DR UCSC; uc007nyr.1; mouse. [Q6DG52-2]
DR CTD; 91612; -.
DR MGI; MGI:1923684; Churc1.
DR VEuPathDB; HostDB:ENSMUSG00000090258; -.
DR eggNOG; ENOG502S4AE; Eukaryota.
DR GeneTree; ENSGT00390000011163; -.
DR HOGENOM; CLU_142022_0_0_1; -.
DR InParanoid; Q6DG52; -.
DR OMA; GTICLEN; -.
DR OrthoDB; 1549523at2759; -.
DR PhylomeDB; Q6DG52; -.
DR TreeFam; TF333004; -.
DR BioGRID-ORCS; 211151; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Churc1; mouse.
DR PRO; PR:Q6DG52; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q6DG52; protein.
DR Bgee; ENSMUSG00000090258; Expressed in right kidney and 67 other tissues.
DR ExpressionAtlas; Q6DG52; baseline and differential.
DR Genevisible; Q6DG52; MM.
DR GO; GO:0005634; C:nucleus; ISA:MGI.
DR GO; GO:0003677; F:DNA binding; ISO:MGI.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007498; P:mesoderm development; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR Gene3D; 2.60.40.4240; -; 1.
DR InterPro; IPR038543; Churchill_sf.
DR InterPro; IPR009508; Transcrpt_activator_Churchill.
DR PANTHER; PTHR31931; PTHR31931; 1.
DR Pfam; PF06573; Churchill; 1.
PE 3: Inferred from homology;
KW Activator; Alternative splicing; Developmental protein; Metal-binding;
KW Reference proteome; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..112
FT /note="Protein Churchill"
FT /id="PRO_0000089666"
FT BINDING 2
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 5
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 30
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 30
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 33
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 59
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 61
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 64
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 66
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 71
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 88
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 91
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT VAR_SEQ 59..70
FT /note="HLCKNCHHVVAR -> RIYHAVSVVWQS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_013378"
FT VAR_SEQ 71..112
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_013379"
SQ SEQUENCE 112 AA; 12858 MW; 6D2AFFA78B9C4947 CRC64;
MCGDCVEKEY PNRGTTCLEN GSFLLNFAGC AVCSKRDFML ITNRSLKEED GEEIVTYDHL
CKNCHHVVAR HEYTFSIMDE FQEYTMLCLL CGKAEDTISI LPDDPRQMTL LF
