ID   CHUR_PONAB              Reviewed;         112 AA.
AC   Q5R6Q5;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 4.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein Churchill;
GN   Name=CHURC1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator that mediates FGF signaling during
CC       neural development (By similarity). Plays a role in the regulation of
CC       cell movement (By similarity). Does not bind DNA by itself (By
CC       similarity). {ECO:0000250|UniProtKB:Q5U3N7,
CC       ECO:0000250|UniProtKB:Q8WUH1, ECO:0000250|UniProtKB:Q9DFZ3}.
CC   -!- SIMILARITY: Belongs to the Churchill family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH92555.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CR860430; CAH92555.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001126496.1; NM_001133024.1.
DR   AlphaFoldDB; Q5R6Q5; -.
DR   BMRB; Q5R6Q5; -.
DR   SMR; Q5R6Q5; -.
DR   STRING; 9601.ENSPPYP00000006713; -.
DR   Ensembl; ENSPPYT00000039376; ENSPPYP00000042374; ENSPPYG00000005906.
DR   GeneID; 100173484; -.
DR   KEGG; pon:100173484; -.
DR   CTD; 91612; -.
DR   eggNOG; ENOG502S4AE; Eukaryota.
DR   GeneTree; ENSGT00390000011163; -.
DR   HOGENOM; CLU_142022_0_0_1; -.
DR   InParanoid; Q5R6Q5; -.
DR   OMA; GTICLEN; -.
DR   OrthoDB; 1549523at2759; -.
DR   TreeFam; TF333004; -.
DR   Proteomes; UP000001595; Chromosome 14.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.60.40.4240; -; 1.
DR   InterPro; IPR038543; Churchill_sf.
DR   InterPro; IPR009508; Transcrpt_activator_Churchill.
DR   PANTHER; PTHR31931; PTHR31931; 1.
DR   Pfam; PF06573; Churchill; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; Metal-binding; Reference proteome;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..112
FT                   /note="Protein Churchill"
FT                   /id="PRO_0000089667"
FT   BINDING         2
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         5
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         30
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         30
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         33
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         59
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         61
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         64
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         66
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         71
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         88
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         91
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   112 AA;  12887 MW;  C817115321C29EC3 CRC64;
     MCGDCVEKEY PNRGNTCLEN GSFLLNFTGC AVCSKRDFML ITNKSLKEED GEEIVTYDHL
     CKNCHHVIAR HEYTFSIMDE FQEYTMLCLL CGKAEDTISI LPDDPRQMTL LF