ID   CHUR_XENLA              Reviewed;         112 AA.
AC   Q9DFZ4; Q0IHD2;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Protein Churchill;
GN   Name=churc1; Synonyms=chch;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14651851; DOI=10.1016/s0092-8674(03)00927-9;
RA   Sheng G., dos Reis M., Stern C.D.;
RT   "Churchill, a zinc finger transcriptional activator, regulates the
RT   transition between gastrulation and neurulation.";
RL   Cell 115:603-613(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fat body;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator that mediates FGF signaling during
CC       neural development (By similarity). Plays a role in the regulation of
CC       cell movement (By similarity). Does not bind DNA by itself (By
CC       similarity). {ECO:0000250|UniProtKB:Q5U3N7,
CC       ECO:0000250|UniProtKB:Q8WUH1, ECO:0000250|UniProtKB:Q9DFZ3}.
CC   -!- SIMILARITY: Belongs to the Churchill family. {ECO:0000305}.
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DR   EMBL; AF238862; AAG09759.1; -; mRNA.
DR   EMBL; BC123207; AAI23208.1; -; mRNA.
DR   RefSeq; NP_001079208.1; NM_001085739.1.
DR   AlphaFoldDB; Q9DFZ4; -.
DR   SMR; Q9DFZ4; -.
DR   DNASU; 373819; -.
DR   GeneID; 373819; -.
DR   KEGG; xla:373819; -.
DR   CTD; 373819; -.
DR   Xenbase; XB-GENE-6252415; churc1.S.
DR   OMA; GTICLEN; -.
DR   OrthoDB; 1549523at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 373819; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.60.40.4240; -; 1.
DR   InterPro; IPR038543; Churchill_sf.
DR   InterPro; IPR009508; Transcrpt_activator_Churchill.
DR   PANTHER; PTHR31931; PTHR31931; 1.
DR   Pfam; PF06573; Churchill; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; Metal-binding; Reference proteome;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..112
FT                   /note="Protein Churchill"
FT                   /id="PRO_0000089668"
FT   BINDING         2
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         5
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         30
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         30
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         33
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         59
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         61
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         64
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         66
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         71
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         88
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         91
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   112 AA;  12731 MW;  7E7E987B47F73EB0 CRC64;
     MCGGCVQQEY PDRGSTCLET GSYLLNYVSC VQCNKRDFVL IVNKTAAEED GEEIITYDHM
     CKNCHHVIAK HEYTFSVVDD YQEYTMLCML CGRAEDSVSV LPDDPRQMAP LF