ID   CHUR_XENTR              Reviewed;         112 AA.
AC   Q66JD9;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Protein Churchill;
GN   Name=churc1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator that mediates FGF signaling during
CC       neural development (By similarity). Plays a role in the regulation of
CC       cell movement (By similarity). Does not bind DNA by itself (By
CC       similarity). {ECO:0000250|UniProtKB:Q5U3N7,
CC       ECO:0000250|UniProtKB:Q8WUH1, ECO:0000250|UniProtKB:Q9DFZ3}.
CC   -!- SIMILARITY: Belongs to the Churchill family. {ECO:0000305}.
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DR   EMBL; BC080951; AAH80951.1; -; mRNA.
DR   RefSeq; NP_001008064.1; NM_001008063.1.
DR   AlphaFoldDB; Q66JD9; -.
DR   SMR; Q66JD9; -.
DR   STRING; 8364.ENSXETP00000057106; -.
DR   PaxDb; Q66JD9; -.
DR   DNASU; 493426; -.
DR   Ensembl; ENSXETT00000076310; ENSXETP00000088920; ENSXETG00000039130.
DR   GeneID; 493426; -.
DR   KEGG; xtr:493426; -.
DR   CTD; 91612; -.
DR   Xenbase; XB-GENE-853240; churc1.
DR   eggNOG; ENOG502S4AE; Eukaryota.
DR   InParanoid; Q66JD9; -.
DR   OrthoDB; 1549523at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000039130; Expressed in skeletal muscle tissue and 12 other tissues.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.60.40.4240; -; 1.
DR   InterPro; IPR038543; Churchill_sf.
DR   InterPro; IPR009508; Transcrpt_activator_Churchill.
DR   PANTHER; PTHR31931; PTHR31931; 1.
DR   Pfam; PF06573; Churchill; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; Metal-binding; Reference proteome;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..112
FT                   /note="Protein Churchill"
FT                   /id="PRO_0000351553"
FT   BINDING         2
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         5
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         30
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         30
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         33
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         59
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         61
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         64
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         66
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         71
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         88
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         91
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   112 AA;  12774 MW;  6E27A5F4F5CAA15B CRC64;
     MCGGCVQEEY PDRGSTCLET GSFLLNYVSC VQCNKRDFVL IVNKTAEEED GEEIITYDHM
     CKNCHHVIAK HEYTFSVVDD YQEYTMLCML CGRAEDSVSV LPDDPRQMAP LF