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CHVG_AGRFC
ID   CHVG_AGRFC              Reviewed;         596 AA.
AC   Q07737;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   27-MAR-2002, sequence version 2.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Sensor protein ChvG;
DE            EC=2.7.13.3;
GN   Name=chvG; OrderedLocusNames=Atu0033; ORFNames=AGR_C_52;
OS   Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
OS   (strain C58)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8407839; DOI=10.1128/jb.175.20.6614-6625.1993;
RA   Charles T.C., Nester E.W.;
RT   "A chromosomally encoded two-component sensory transduction system is
RT   required for virulence of Agrobacterium tumefaciens.";
RL   J. Bacteriol. 175:6614-6625(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743193; DOI=10.1126/science.1066804;
RA   Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K.,
RA   Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y.,
RA   Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P.,
RA   Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R.,
RA   Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G.,
RA   Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y.,
RA   Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S.,
RA   Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F.,
RA   Gordon M.P., Olson M.V., Nester E.W.;
RT   "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT   C58.";
RL   Science 294:2317-2323(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743194; DOI=10.1126/science.1066803;
RA   Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B.,
RA   Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K.,
RA   Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M.,
RA   Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C.,
RA   Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
RT   "Genome sequence of the plant pathogen and biotechnology agent
RT   Agrobacterium tumefaciens C58.";
RL   Science 294:2323-2328(2001).
CC   -!- FUNCTION: Member of a two-component regulatory system ChvG/ChvI.
CC       Activates ChvI by phosphorylation (Potential). {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA03552.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L18860; AAA03552.1; ALT_FRAME; Unassigned_DNA.
DR   EMBL; AE007869; AAK85857.1; -; Genomic_DNA.
DR   PIR; A49902; A49902.
DR   PIR; AB2581; AB2581.
DR   PIR; H97362; H97362.
DR   RefSeq; NP_353072.1; NC_003062.2.
DR   RefSeq; WP_006311105.1; NC_003062.2.
DR   AlphaFoldDB; Q07737; -.
DR   SMR; Q07737; -.
DR   STRING; 176299.Atu0033; -.
DR   EnsemblBacteria; AAK85857; AAK85857; Atu0033.
DR   GeneID; 66223049; -.
DR   KEGG; atu:Atu0033; -.
DR   PATRIC; fig|176299.10.peg.33; -.
DR   eggNOG; COG0642; Bacteria.
DR   HOGENOM; CLU_000445_89_6_5; -.
DR   OMA; VIWAENI; -.
DR   PhylomeDB; Q07737; -.
DR   BioCyc; AGRO:ATU0033-MON; -.
DR   BRENDA; 2.7.13.3; 200.
DR   Proteomes; UP000000813; Chromosome circular.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR025908; Sensor_TM1.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR025919; Stimulus_sens_dom.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF13755; Sensor_TM1; 1.
DR   Pfam; PF13756; Stimulus_sens_1; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Kinase; Membrane;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase;
KW   Transmembrane; Transmembrane helix; Two-component regulatory system.
FT   CHAIN           1..596
FT                   /note="Sensor protein ChvG"
FT                   /id="PRO_0000074720"
FT   TOPO_DOM        1..47
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..283
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        305..596
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          301..356
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          364..592
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         367
FT                   /note="Phosphohistidine"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        94
FT                   /note="A -> R (in Ref. 1; AAA03552)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        236
FT                   /note="R -> P (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        314..318
FT                   /note="AIRVR -> RSGA (in Ref. 1; AAA03552)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   596 AA;  65722 MW;  8931990E49736C4B CRC64;
     MLKKTPETVS DSDDAEERGS ERRHRIHPLT IIRRIFGNAV FSSLTRRILF FNVAATVVLV
     GGILYLNQFR EGLIDARVES LLTQGEIIAG AVSASASVDT NSITINPEKL LELQAGQSIT
     PAPNDEDLSF PINPERVAPV LRRLISPTRT RARLFDADAN LLLDSRHLYS RGQVLRFDLP
     PVTPETQTWG DWFTSMFNRM LQPSSLPQYK EAPGGDGSIY PEVMNALTGV RGAVVRVTEK
     GELIVSVAVP VQRFRAVLGV LLLSTQAGDI DKIVHAERLA IMRVFGIATL VNIVLSLLLS
     STIATPLRRL SAAAIRVRRG ARTREEIPDF SARQDEIGNL SIALREMTTA LYDRIDAIES
     FAADVSHELK NPLTSLRSAV ETLPRAKTEE SKQRLTEIIF HDVRRLDRLI SDISDASRLD
     AELARADASP LDLDVLMKGL VDISRQISTK KKSVAIDYVA DRKAGAKTSF VVNGHDLRIG
     QIVTNLIENA RSFVSEESGR ITVRLSRHKD RCIVQVEDNG PGIQAEDIDR IFERFYTDRP
     ASEGFGQNSG LGLSISRQIA EAHGGSLRAE NVVDKYGVIS GARFTLSLPA AETHER
 
 
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