CHX10_ARATH
ID CHX10_ARATH Reviewed; 783 AA.
AC Q58P69; Q9FYB8;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Cation/H(+) antiporter 10;
DE AltName: Full=Protein CATION/H+ EXCHANGER 10;
DE Short=AtCHX10;
GN Name=CHX10; OrderedLocusNames=At3g44930; ORFNames=F28D10_120;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-780, TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC TISSUE=Pollen;
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in pollen.
CC {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC03543.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL391254; CAC03543.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002686; AEE77969.1; -; Genomic_DNA.
DR EMBL; AY926470; AAX49542.1; -; mRNA.
DR PIR; T51790; T51790.
DR RefSeq; NP_190079.2; NM_114362.3.
DR AlphaFoldDB; Q58P69; -.
DR SMR; Q58P69; -.
DR BioGRID; 8947; 7.
DR IntAct; Q58P69; 6.
DR STRING; 3702.AT3G44930.1; -.
DR PaxDb; Q58P69; -.
DR PRIDE; Q58P69; -.
DR ProteomicsDB; 246836; -.
DR EnsemblPlants; AT3G44930.1; AT3G44930.1; AT3G44930.
DR GeneID; 823627; -.
DR Gramene; AT3G44930.1; AT3G44930.1; AT3G44930.
DR KEGG; ath:AT3G44930; -.
DR Araport; AT3G44930; -.
DR TAIR; locus:2082102; AT3G44930.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_1_1; -.
DR InParanoid; Q58P69; -.
DR OMA; VHETTET; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q58P69; -.
DR PRO; PR:Q58P69; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q58P69; baseline.
DR Genevisible; Q58P69; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..783
FT /note="Cation/H(+) antiporter 10"
FT /id="PRO_0000394981"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 783 AA; 88143 MW; BE72737B5BB8301D CRC64;
MNTTTYIGDC RISFFNISSQ GFWDNLKSPD VVFGYSLPLL EIQIILIFFC IVMSHMFLRC
IGISQIASYM IAGIVLGPQL FDVLEKSSGK LSVDPALDGI AALRCISVFG TLMFTFLMTV
RTSRRVAFHS GKLPVVIGIV SFFAPLFGLG FQNFFSDNID PHYMPLTKAL GERTAIVITQ
SSILLPSTTY ILLELKIINS ELGRLALSAC VINDILGIFS MIVASIQATY IHVSHATAYR
DTVAVIIFFL VVFLVFKPMV QWVIDRTPED KPVEDMYIHA VIITALASAA YFVFFNMKYI
LGPLMIGIII PEGPPLGSAL EAKFERLTMN VFLPISITFS AMRCDGARIL SQFNDIFFNI
FLTFLILVIK LVACLAPCLY YKLPLSESLA VSFILSYKSF ADFVLYEAVL DDTYISQATY
SFLILYSLLN AGIVPTVLRR MYDPRRKYVN YQKRDILHLE RNSDLRILTC LHKPENVSET
IAFLQLLSSP NLDFPIAVTV LHLVKLVGQI NPIIVSHDKK LKRLNKDSYI HTANLAFRQF
VLESLESVTV TTFTAFSHEN LMHEDICTLA LDKTTSMIVV PSGRKWTVDG LFESDNTAIR
HLNQSLLDRA PCSIGILVDR GQFSRKSIVT SKKRYIIDVG VLFIGGKDDR EALSLVKRMK
NNPRIRVTVI RLVFDHEIES DWDYILDNEG LKDLKSTEDN KDIDYIERIV TSSVEVVKAV
QLLAEEYDLM VVGRDHDMTS QDLSGLMEWV ELPELGVIGD LLAARDLSSK VSVLVVQQQQ
QRT
