CHX11_ARATH
ID CHX11_ARATH Reviewed; 783 AA.
AC Q9FYB9;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Cation/H(+) antiporter 11;
DE AltName: Full=Protein CATION/H+ EXCHANGER 11;
DE Short=AtCHX11;
GN Name=CHX11; OrderedLocusNames=At3g44920; ORFNames=F28D10_110;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in pollen.
CC {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC03542.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL391254; CAC03542.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE77968.1; -; Genomic_DNA.
DR PIR; T51789; T51789.
DR RefSeq; NP_190078.2; NM_114361.3.
DR AlphaFoldDB; Q9FYB9; -.
DR STRING; 3702.AT3G44920.1; -.
DR PaxDb; Q9FYB9; -.
DR PRIDE; Q9FYB9; -.
DR ProteomicsDB; 246837; -.
DR EnsemblPlants; AT3G44920.1; AT3G44920.1; AT3G44920.
DR GeneID; 823626; -.
DR Gramene; AT3G44920.1; AT3G44920.1; AT3G44920.
DR KEGG; ath:AT3G44920; -.
DR Araport; AT3G44920; -.
DR TAIR; locus:2082152; AT3G44920.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_1_1; -.
DR InParanoid; Q9FYB9; -.
DR OMA; IESEWDY; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q9FYB9; -.
DR PRO; PR:Q9FYB9; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9FYB9; baseline and differential.
DR Genevisible; Q9FYB9; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..783
FT /note="Cation/H(+) antiporter 11"
FT /id="PRO_0000394982"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 783 AA; 88433 MW; 47E63069577C1AF5 CRC64;
MNTTTYIGHC RISFFNISSQ GFWENLKSPD VVFGYSLPLL EIQIILIFFC IVMSHMFLRC
IGVSQIVSYM IAGLILGPQL FDILEKSSGK LSADPALDGT AALRCISVFG RLMFTFLMTV
RTSRRVAFHS GKLPVVIGIV SFFAPLFSLS FLNLFTDNID PHYMSLDKAL AERTVIVITQ
SQILLPSTTY ILLELKIINS ELGRLALSAS AINDMLGIFA MIVATTQATY IHVSHAIAYR
DLVAVIIFFL IVFFVFKPMV QWIIDRTPED KPVEDIYIHA VILTAFASAA YFVFFNMKYV
LGPLIIGIII PEGPPLGSAL EAKFERLTMN VFLPISITFS AMRCDGLRIL SQFTDIYFNI
FLTLLILVIK LVACLTLCLY YKLPRSESLA VSLILSYKSF VEFVLYEAVL EEKFISQATY
AFLILYSLLS AGIVPMVVRS MYDPKRKYVN YQKRDILHLE ANSGLRILTC LHKPENVSET
IAFLQLFSSP IHDFPIAVTV LHLVKLVGQI NPIIVSHDKK LKRLHKNSYI HTANLAFRQF
MQESLESVTV TTFTAFSHEN LMHEDICTLA LDRTTSMIVV PSGRKWTVDG MFESDDLAAR
QLNQSLLDRA PCSIGILVDR GQFSRKSYVT SKNRYNIDVG VLFIGGKDDR EALSLVKRMK
YNPRVRVTVI RLIFDHEIES EWDYILDNEG LKDLKSTESN EDILYTERIV TSVVEVVKAV
QLLAEEYDLM VVGRDHDMTS QDLSGLTEWV ELPELGVIGD LLAARDLNSK VSVLVVQQQQ
QQT
