CHX12_ARATH
ID CHX12_ARATH Reviewed; 770 AA.
AC Q9FYC0;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Cation/H(+) antiporter 12;
DE AltName: Full=Protein CATION/H+ EXCHANGER 12;
DE Short=AtCHX12;
GN Name=CHX12; OrderedLocusNames=At3g44910; ORFNames=F28D10_100;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in pollen. {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC03541.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL391254; CAC03541.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE77967.1; -; Genomic_DNA.
DR PIR; T51788; T51788.
DR RefSeq; NP_190077.2; NM_114360.2.
DR AlphaFoldDB; Q9FYC0; -.
DR SMR; Q9FYC0; -.
DR STRING; 3702.AT3G44910.1; -.
DR PaxDb; Q9FYC0; -.
DR PRIDE; Q9FYC0; -.
DR EnsemblPlants; AT3G44910.1; AT3G44910.1; AT3G44910.
DR GeneID; 823625; -.
DR Gramene; AT3G44910.1; AT3G44910.1; AT3G44910.
DR KEGG; ath:AT3G44910; -.
DR Araport; AT3G44910; -.
DR TAIR; locus:2082137; AT3G44910.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_1_1; -.
DR InParanoid; Q9FYC0; -.
DR OMA; NISPMTA; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q9FYC0; -.
DR PRO; PR:Q9FYC0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9FYC0; differential.
DR Genevisible; Q9FYC0; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..770
FT /note="Cation/H(+) antiporter 12"
FT /id="PRO_0000394983"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 770 AA; 85819 MW; 72E11A56B599FA6F CRC64;
MNTTSYIRGC IPLVFNISSF GFWENLKSPD VIFGYSLPLM EFQILLIFVF IIIIHSFLKS
FGISPIPSYM LAGLILGPQL FNLREVSSRK LSWDPALDGN GPLRGLSVCG NIMLAFFMTV
KISRRLAFNN GWLPIVIGTL SFIVPFLGGF CVRNLHTDNI DPYYMSPNKV LAERIVVISS
QSSILLPTVV HFLSELKILN SELGRLVLSA SLINDIFAST VSIFAYLVGT YKNISPMTAY
RDLIAVIILI LVAFCVLRPV VEWIVERTPE GKPVADVYVH AVVLSVIASA AYSSFFNMKY
LLGPFLLGII IPEGPPIGSA LEAKYEALTM NVLIPISITF STMRCDVMKI VYQYDDIWYN
IFLMTFTGFL KMATGMVPCL YCKIPFKEAI AASLLLCSKS FSEIFLYEST YDDSYISQAT
YTFLITCALI NSGIIPTALA GLYDPKRKYV GYQKKNIMNL KPDSDLRILT CIHRPENISA
AISFLQFLPS TIVVTVLHLV KLVGKTVPVL ISHNKQINRV VTNSYIHTAN LAFSQLESVT
MTMFTAITHE NLMHDEICKV ALEQATSIII VPSGRKWTVD GAFESEDEAI RRLNESLLKS
ASCSIGILVD RGQLSLKGTR KFNIDVGVIF IGGKDDREAL SLVKKMKQNP RVKITVIRLI
SDRETESTNW DYILDHEVLE DLKDTEATNS IAYTERIVTG GPEVATTVRS LSEDYDLMVV
GRDHGMASPD FDGLMEWVEL PELGVIGDLL ASRELDSRVS VLVVQQQQQT
