CHX14_ARATH
ID CHX14_ARATH Reviewed; 829 AA.
AC Q9LMJ1;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Cation/H(+) antiporter 14;
DE AltName: Full=Protein CATION/H+ EXCHANGER 14;
DE Short=AtCHX14;
GN Name=CHX14; OrderedLocusNames=At1g06970; ORFNames=F10K1.31;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=18676662; DOI=10.1104/pp.108.124248;
RA Zhao J., Cheng N.-H., Motes C.M., Blancaflor E.B., Moore M., Gonzales N.,
RA Padmanaban S., Sze H., Ward J.M., Hirschi K.D.;
RT "AtCHX13 is a plasma membrane K+ transporter.";
RL Plant Physiol. 148:796-807(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [6]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in pollen but also
CC detected in vegetative tissues like leaf trichomes and root vascular
CC tissues. {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
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DR EMBL; EF571900; ABS19937.1; -; mRNA.
DR EMBL; AC067971; AAF82222.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28061.1; -; Genomic_DNA.
DR EMBL; DQ446234; ABE65605.1; -; mRNA.
DR PIR; D86204; D86204.
DR RefSeq; NP_172178.1; NM_100570.2.
DR AlphaFoldDB; Q9LMJ1; -.
DR SMR; Q9LMJ1; -.
DR STRING; 3702.AT1G06970.1; -.
DR iPTMnet; Q9LMJ1; -.
DR PaxDb; Q9LMJ1; -.
DR PRIDE; Q9LMJ1; -.
DR ProteomicsDB; 246839; -.
DR EnsemblPlants; AT1G06970.1; AT1G06970.1; AT1G06970.
DR GeneID; 837207; -.
DR Gramene; AT1G06970.1; AT1G06970.1; AT1G06970.
DR KEGG; ath:AT1G06970; -.
DR Araport; AT1G06970; -.
DR TAIR; locus:2007392; AT1G06970.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_1_1; -.
DR InParanoid; Q9LMJ1; -.
DR OMA; FKMGVQI; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q9LMJ1; -.
DR PRO; PR:Q9LMJ1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LMJ1; baseline and differential.
DR Genevisible; Q9LMJ1; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Phosphoprotein; Potassium;
KW Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..829
FT /note="Cation/H(+) antiporter 14"
FT /id="PRO_0000394984"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 827
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9SUQ7"
SQ SEQUENCE 829 AA; 92160 MW; 2DB677679A6CB5EE CRC64;
MSKLDLEEVN SMQRGKVHGP FLVENMVCQK NHMLTSKGVF LGSDPLKYAM PLMLLQMSVI
IITSRLLYRL LKPLKQGMIS AQVLAGIILG PSLFGQSSAY MQMFLPISGK ITLQTLSNLG
FFIHLFLLGL RIDASIIRKA GSKAILIGTA SYALPFSLGN LTVLFLKNTY NLPPDVVHCI
STVISLNAMT SFPVTTTVLA ELNILNSDLG RLATNCSIVC EAFSWIVALV FRMFLRDGTL
ASVWSFVWVT ALILVIFFVC RPAIIWLTER RSISIDKAGE IPFFPIIMVL LTISLTSEVL
GVHAAFGAFW LGVSLPDGPP LGTGLTTKLE MFATSLMLPC FISISGLQTN FFIIGESHVK
IIEAVILITY GCKFLGTAAA SAYCNIQIGD AFSLALLMCC QGVIEIYTCV MWKDEKVLNT
ECFNLLIITL LLVTGISRFL VVCLYDPSKR YRSKSKRTIL DTRQRNLQFR LLLCVYNVEN
VPSMVNLLEA SYPSRFSPIS VFTLHLVELK GRAHAVLVPH HQMNKLDPNT VQSTHIVNGF
QRFEQQNQGT LMAQHFTAAA PFSSINDDIC TLALDKKATL IVIPFHKQYA IDGTVDHVNP
SIRNINLNVL EKAPCSVGIF IDRGETEGRR SVLMSYTWRN VAVIFIEGRD DAEALAFSMR
IAEHPEVSVT MIHFRHKSSL QQNHVVDVES ELAESYLIND FKNFAMSKPK ISYREEIVRD
GVETTQVISS LGDSFDLVVV GRDHDLESSV LYGLTDWSEC PELGVIGDMF ASSDFHFSVL
VIHQQEGDSL AMDNSYKLPA SPHRVGDPRV HPRFSVEEGF TSVDLHSNR
