CHX15_ARATH
ID CHX15_ARATH Reviewed; 821 AA.
AC Q9SIT5;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Cation/H(+) antiporter 15;
DE AltName: Full=Protein CATION/H+ EXCHANGER 15;
DE Short=AtCHX15;
GN Name=CHX15; OrderedLocusNames=At2g13620; ORFNames=T10F5.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC TISSUE=Pollen;
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in pollen.
CC {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
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DR EMBL; AY926472; AAX49544.1; -; mRNA.
DR EMBL; AC007063; AAD22684.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06246.1; -; Genomic_DNA.
DR PIR; B84509; B84509.
DR RefSeq; NP_178985.1; NM_126941.2.
DR AlphaFoldDB; Q9SIT5; -.
DR SMR; Q9SIT5; -.
DR STRING; 3702.AT2G13620.1; -.
DR PaxDb; Q9SIT5; -.
DR PRIDE; Q9SIT5; -.
DR ProteomicsDB; 246840; -.
DR EnsemblPlants; AT2G13620.1; AT2G13620.1; AT2G13620.
DR GeneID; 815847; -.
DR Gramene; AT2G13620.1; AT2G13620.1; AT2G13620.
DR KEGG; ath:AT2G13620; -.
DR Araport; AT2G13620; -.
DR TAIR; locus:2054152; AT2G13620.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_2_1; -.
DR InParanoid; Q9SIT5; -.
DR OMA; ASDHIFN; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q9SIT5; -.
DR PRO; PR:Q9SIT5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SIT5; baseline and differential.
DR Genevisible; Q9SIT5; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IMP:TAIR.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..821
FT /note="Cation/H(+) antiporter 15"
FT /id="PRO_0000394985"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 800..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 89860 MW; 85A49DBC2C35DD7F CRC64;
MATSEEPSTD ASIICYAPSM ITTNGVWQGD NPLDFSLPLF VLQLTLVVVV TRFFVFILKP
FRQPRVISEI LGGIVLGPSV LGRSTKFAHT IFPQRSVMVL ETMANVGLLY FLFLVGVEMD
IMVVRKTGKR ALTIAIGGMV LPFLIGAAFS FSMHRSEDHL GQGTYILFLG VALSVTAFPV
LARILAELKL INTEIGRISM SAALVNDMFA WILLALAIAL AESDKTSFAS LWVMISSAVF
IAVCVFVVRP GIAWIIRKTP EGENFSEFHI CLILTGVMIS GFITDAIGTH SVFGAFVFGL
VIPNGPLGLT LIEKLEDFVS GLLLPLFFAI SGLKTNIAAI QGPATWLTLF LVIFLACAGK
VIGTVIVAFF HGMPVREGIT LGLLLNTKGL VEMIVLNVGK DQKVLDDETF ATMVLVALVM
TGVITPIVTI LYKPVKKSVS YKRRTIQQTK PDSELRVLVC VHTPRNVPTI INLLEASHPT
KRSPICIYVL HLVELTGRAS AMLIVHNTRK SGRPALNRTQ AQSDHIINAF ENYEQHAAFV
AVQPLTAISP YSTMHEDVCS LAEDKRVSFI IIPFHKQQTV DGGMESTNPA YRLVNQNLLE
NSPCSVGILV DRGLNGATRL NSNTVSLQVA VLFFGGPDDR EALAYAWRMA QHPGITLTVL
RFIHDEDEAD TASTRATNDS DLKIPKMDHR KQRQLDDDYI NLFRAENAEY ESIVYIEKLV
SNGEETVAAV RSMDSSHDLF IVGRGEGMSS PLTAGLTDWS ECPELGAIGD LLASSDFAAT
VSVLVVQQYV GSWAQEDDMD FPESPVHSHE TKVTYGLENP R
