CHX16_ARATH
ID CHX16_ARATH Reviewed; 811 AA.
AC Q1HDT3; Q9SH67;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Cation/H(+) antiporter 16;
DE AltName: Full=Protein CATION/H+ EXCHANGER 16;
DE Short=AtCHX16;
GN Name=CHX16; OrderedLocusNames=At1g64170; ORFNames=F22C12.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC TISSUE=Pollen;
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves and roots.
CC {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF24561.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DQ499021; ABF54931.1; -; mRNA.
DR EMBL; AC007764; AAF24561.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34204.1; -; Genomic_DNA.
DR RefSeq; NP_176599.2; NM_105090.4.
DR AlphaFoldDB; Q1HDT3; -.
DR SMR; Q1HDT3; -.
DR STRING; 3702.AT1G64170.1; -.
DR PaxDb; Q1HDT3; -.
DR PRIDE; Q1HDT3; -.
DR ProteomicsDB; 246841; -.
DR EnsemblPlants; AT1G64170.1; AT1G64170.1; AT1G64170.
DR GeneID; 842721; -.
DR Gramene; AT1G64170.1; AT1G64170.1; AT1G64170.
DR KEGG; ath:AT1G64170; -.
DR Araport; AT1G64170; -.
DR TAIR; locus:2024578; AT1G64170.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_2_1; -.
DR InParanoid; Q1HDT3; -.
DR OMA; TIPAMKC; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q1HDT3; -.
DR PRO; PR:Q1HDT3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q1HDT3; baseline and differential.
DR Genevisible; Q1HDT3; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IMP:TAIR.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..811
FT /note="Cation/H(+) antiporter 16"
FT /id="PRO_0000394986"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 811 AA; 88051 MW; 116FAFFBF006EEBD CRC64;
MGTLVNGTIP AMKCPKNVAM MKTTSNGVFD GESPLDFAFP LVILQICLVV AVTRSLAFLL
RPMRQPRVVA EIIGGILLGP SALGRITSYK NSIFPARSLT VLDTLANLGL LLFLFLVGLE
IDLTSLRRTG KKAISIAAAG MLLPFGMGIV TSFAFPEASS SGDNSKVLPF IIFMGVALSI
TAFGVLARIL AELKLLTTDL GRISMNAAAI NDVAAWVLLA LAVSLSGDRN SPLVPLWVLL
SGIAFVIACF LIVPRIFKFI SRRCPEGEPI GEMYVCVALC AVLLAGFATD AIGIHAIFGA
FVMGVLFPKG HFSDAIVEKI EDLVMGLLLP LYFVMSGLKT DITTIQGVKS WGRLALVIVT
ACFGKIVGTV SVALLCKVRL RESVVLGVLM NTKGLVELIV LNIGKDRKVL SDQTFAIMVL
MAIFTTFITT PIVLALYKPS ETTQTHSSVS YKNRKHRRKI ENDEEGEKMQ QLKVLVCLQS
SKDIDPMMKI MEATRGSNET KERFCVYVMH LTQLSERPSS IRMVQKVRSN GLPFWNKKRE
NSSAVTVAFE ASSKLSSVSV RSVTAISPLS TIHEDICSSA DSKCTAFVIL PFHKQWRSLE
KEFETVRSEY QGINKRVLEN SPCSVGILVD RGLGDNNSPV ASSNFSLSVN VLFFGGCDDR
EALVYGLRMA EHPGVNLTVV VISGPESARF DRLEAQETSL CSLDEQFLAA IKKRANAARF
EERTVNSTEE VVEIIRQFYE CDILLVGKSS KGPMVSRLPV MKIECPELGP VGNLIVSNEI
STSVSVLVVQ QYTGKGPSVV GSVSVPVVET P
