CHX18_ARATH
ID CHX18_ARATH Reviewed; 810 AA.
AC Q9FFR9; Q3E7L5; Q58P65;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Cation/H(+) antiporter 18;
DE AltName: Full=Protein CATION/H+ EXCHANGER 18;
DE Short=AtCHX18;
GN Name=CHX18; OrderedLocusNames=At5g41610; ORFNames=MBK23.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-808 (ISOFORM 1), TISSUE SPECIFICITY, GENE
RP FAMILY, AND NOMENCLATURE.
RC TISSUE=Pollen;
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9FFR9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FFR9-2; Sequence=VSP_039314;
CC -!- TISSUE SPECIFICITY: Expressed in roots. {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB005233; BAB11467.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94697.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94698.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM70858.1; -; Genomic_DNA.
DR EMBL; AY926474; AAX49546.1; -; mRNA.
DR RefSeq; NP_001318723.1; NM_001344404.1. [Q9FFR9-2]
DR RefSeq; NP_001332436.1; NM_001344405.1. [Q9FFR9-1]
DR RefSeq; NP_198976.3; NM_123525.4. [Q9FFR9-1]
DR AlphaFoldDB; Q9FFR9; -.
DR SMR; Q9FFR9; -.
DR BioGRID; 19414; 4.
DR IntAct; Q9FFR9; 4.
DR STRING; 3702.AT5G41610.1; -.
DR PaxDb; Q9FFR9; -.
DR PRIDE; Q9FFR9; -.
DR ProteomicsDB; 246970; -. [Q9FFR9-1]
DR EnsemblPlants; AT5G41610.1; AT5G41610.1; AT5G41610. [Q9FFR9-1]
DR EnsemblPlants; AT5G41610.2; AT5G41610.2; AT5G41610. [Q9FFR9-2]
DR EnsemblPlants; AT5G41610.3; AT5G41610.3; AT5G41610. [Q9FFR9-1]
DR GeneID; 834163; -.
DR Gramene; AT5G41610.1; AT5G41610.1; AT5G41610. [Q9FFR9-1]
DR Gramene; AT5G41610.2; AT5G41610.2; AT5G41610. [Q9FFR9-2]
DR Gramene; AT5G41610.3; AT5G41610.3; AT5G41610. [Q9FFR9-1]
DR KEGG; ath:AT5G41610; -.
DR Araport; AT5G41610; -.
DR TAIR; locus:2160457; AT5G41610.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_2_1; -.
DR InParanoid; Q9FFR9; -.
DR OMA; GQKCPSP; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q9FFR9; -.
DR PRO; PR:Q9FFR9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FFR9; baseline and differential.
DR Genevisible; Q9FFR9; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; IDA:TAIR.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IMP:TAIR.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Antiport; Ion transport; Membrane; Phosphoprotein;
KW Potassium; Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..810
FT /note="Cation/H(+) antiporter 18"
FT /id="PRO_0000394988"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 804
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9SUQ7"
FT VAR_SEQ 1..68
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_039314"
SQ SEQUENCE 810 AA; 87383 MW; 4FADAD2DD49917E2 CRC64;
MATNSTKACP APMKATSNGV FQGDNPIDFA LPLAILQIVI VIVLTRVLAY LLRPLRQPRV
IAEVIGGIML GPSLLGRSKA FLDAVFPKKS LTVLETLANL GLLFFLFLAG LEIDTKALRR
TGKKALGIAL AGITLPFALG IGSSFVLKAT ISKGVNSTAF LVFMGVALSI TAFPVLARIL
AELKLLTTEI GRLAMSAAAV NDVAAWILLA LAIALSGSNT SPLVSLWVFL SGCAFVIGAS
FIIPPIFRWI SRRCHEGEPI EETYICATLA VVLVCGFITD AIGIHSMFGA FVVGVLIPKE
GPFAGALVEK VEDLVSGLFL PLYFVASGLK TNVATIQGAQ SWGLLVLVTA TACFGKILGT
LGVSLAFKIP MREAITLGFL MNTKGLVELI VLNIGKDRKV LNDQTFAIMV LMALFTTFIT
TPVVMAVYKP ARRAKKEGEY KHRAVERENT NTQLRILTCF HGAGSIPSMI NLLEASRGIE
KGEGLCVYAL HLRELSERSS AILMVHKVRK NGMPFWNRRG VNADADQVVV AFQAFQQLSR
VNVRPMTAIS SMSDIHEDIC TTAVRKKAAI VILPFHKHQQ LDGSLETTRG DYRWVNRRVL
LQAPCSVGIF VDRGLGGSSQ VSAQDVSYSV VVLFFGGPDD REALAYGLRM AEHPGIVLTV
FRFVVSPERV GEIVNVEVSN NNNENQSVKN LKSDEEIMSE IRKISSVDES VKFVEKQIEN
AAVDVRSAIE EVRRSNLFLV GRMPGGEIAL AIRENSECPE LGPVGSLLIS PESSTKASVL
VIQQYNGTGI APDLGAAETE VLTSTDKDSD