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CHX18_ARATH
ID   CHX18_ARATH             Reviewed;         810 AA.
AC   Q9FFR9; Q3E7L5; Q58P65;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Cation/H(+) antiporter 18;
DE   AltName: Full=Protein CATION/H+ EXCHANGER 18;
DE            Short=AtCHX18;
GN   Name=CHX18; OrderedLocusNames=At5g41610; ORFNames=MBK23.12;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA   Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA   Miyajima N., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT   features of the 1.6 Mb regions covered by twenty physically assigned P1
RT   clones.";
RL   DNA Res. 4:215-230(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-808 (ISOFORM 1), TISSUE SPECIFICITY, GENE
RP   FAMILY, AND NOMENCLATURE.
RC   TISSUE=Pollen;
RX   PubMed=15347787; DOI=10.1104/pp.104.046003;
RA   Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA   Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT   "Expression patterns of a novel AtCHX gene family highlight potential roles
RT   in osmotic adjustment and K+ homeostasis in pollen development.";
RL   Plant Physiol. 136:2532-2547(2004).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA   Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA   Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA   Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT   "Phylogenetic relationships within cation transporter families of
RT   Arabidopsis.";
RL   Plant Physiol. 126:1646-1667(2001).
CC   -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9FFR9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9FFR9-2; Sequence=VSP_039314;
CC   -!- TISSUE SPECIFICITY: Expressed in roots. {ECO:0000269|PubMed:15347787}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AB005233; BAB11467.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED94697.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED94698.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM70858.1; -; Genomic_DNA.
DR   EMBL; AY926474; AAX49546.1; -; mRNA.
DR   RefSeq; NP_001318723.1; NM_001344404.1. [Q9FFR9-2]
DR   RefSeq; NP_001332436.1; NM_001344405.1. [Q9FFR9-1]
DR   RefSeq; NP_198976.3; NM_123525.4. [Q9FFR9-1]
DR   AlphaFoldDB; Q9FFR9; -.
DR   SMR; Q9FFR9; -.
DR   BioGRID; 19414; 4.
DR   IntAct; Q9FFR9; 4.
DR   STRING; 3702.AT5G41610.1; -.
DR   PaxDb; Q9FFR9; -.
DR   PRIDE; Q9FFR9; -.
DR   ProteomicsDB; 246970; -. [Q9FFR9-1]
DR   EnsemblPlants; AT5G41610.1; AT5G41610.1; AT5G41610. [Q9FFR9-1]
DR   EnsemblPlants; AT5G41610.2; AT5G41610.2; AT5G41610. [Q9FFR9-2]
DR   EnsemblPlants; AT5G41610.3; AT5G41610.3; AT5G41610. [Q9FFR9-1]
DR   GeneID; 834163; -.
DR   Gramene; AT5G41610.1; AT5G41610.1; AT5G41610. [Q9FFR9-1]
DR   Gramene; AT5G41610.2; AT5G41610.2; AT5G41610. [Q9FFR9-2]
DR   Gramene; AT5G41610.3; AT5G41610.3; AT5G41610. [Q9FFR9-1]
DR   KEGG; ath:AT5G41610; -.
DR   Araport; AT5G41610; -.
DR   TAIR; locus:2160457; AT5G41610.
DR   eggNOG; KOG1650; Eukaryota.
DR   HOGENOM; CLU_005126_6_2_1; -.
DR   InParanoid; Q9FFR9; -.
DR   OMA; GQKCPSP; -.
DR   OrthoDB; 336706at2759; -.
DR   PhylomeDB; Q9FFR9; -.
DR   PRO; PR:Q9FFR9; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FFR9; baseline and differential.
DR   Genevisible; Q9FFR9; AT.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IDA:TAIR.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0006885; P:regulation of pH; IMP:TAIR.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Antiport; Ion transport; Membrane; Phosphoprotein;
KW   Potassium; Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..810
FT                   /note="Cation/H(+) antiporter 18"
FT                   /id="PRO_0000394988"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         804
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SUQ7"
FT   VAR_SEQ         1..68
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_039314"
SQ   SEQUENCE   810 AA;  87383 MW;  4FADAD2DD49917E2 CRC64;
     MATNSTKACP APMKATSNGV FQGDNPIDFA LPLAILQIVI VIVLTRVLAY LLRPLRQPRV
     IAEVIGGIML GPSLLGRSKA FLDAVFPKKS LTVLETLANL GLLFFLFLAG LEIDTKALRR
     TGKKALGIAL AGITLPFALG IGSSFVLKAT ISKGVNSTAF LVFMGVALSI TAFPVLARIL
     AELKLLTTEI GRLAMSAAAV NDVAAWILLA LAIALSGSNT SPLVSLWVFL SGCAFVIGAS
     FIIPPIFRWI SRRCHEGEPI EETYICATLA VVLVCGFITD AIGIHSMFGA FVVGVLIPKE
     GPFAGALVEK VEDLVSGLFL PLYFVASGLK TNVATIQGAQ SWGLLVLVTA TACFGKILGT
     LGVSLAFKIP MREAITLGFL MNTKGLVELI VLNIGKDRKV LNDQTFAIMV LMALFTTFIT
     TPVVMAVYKP ARRAKKEGEY KHRAVERENT NTQLRILTCF HGAGSIPSMI NLLEASRGIE
     KGEGLCVYAL HLRELSERSS AILMVHKVRK NGMPFWNRRG VNADADQVVV AFQAFQQLSR
     VNVRPMTAIS SMSDIHEDIC TTAVRKKAAI VILPFHKHQQ LDGSLETTRG DYRWVNRRVL
     LQAPCSVGIF VDRGLGGSSQ VSAQDVSYSV VVLFFGGPDD REALAYGLRM AEHPGIVLTV
     FRFVVSPERV GEIVNVEVSN NNNENQSVKN LKSDEEIMSE IRKISSVDES VKFVEKQIEN
     AAVDVRSAIE EVRRSNLFLV GRMPGGEIAL AIRENSECPE LGPVGSLLIS PESSTKASVL
     VIQQYNGTGI APDLGAAETE VLTSTDKDSD
 
 
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