CHX19_ARATH
ID CHX19_ARATH Reviewed; 800 AA.
AC Q9LUN4;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Cation/H(+) antiporter 19;
DE AltName: Full=Protein CATION/H+ EXCHANGER 19;
DE Short=AtCHX19;
GN Name=CHX19; OrderedLocusNames=At3g17630; ORFNames=MKP6.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC TISSUE=Pollen;
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the whole plant but preferentially in
CC pollen. {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
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DR EMBL; AY926475; AAX49547.1; -; mRNA.
DR EMBL; AB022219; BAB02053.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75983.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM63400.1; -; Genomic_DNA.
DR RefSeq; NP_001319577.1; NM_001338295.1.
DR RefSeq; NP_188390.2; NM_112644.3.
DR AlphaFoldDB; Q9LUN4; -.
DR SMR; Q9LUN4; -.
DR BioGRID; 6363; 9.
DR IntAct; Q9LUN4; 6.
DR STRING; 3702.AT3G17630.1; -.
DR PaxDb; Q9LUN4; -.
DR PRIDE; Q9LUN4; -.
DR ProteomicsDB; 246971; -.
DR EnsemblPlants; AT3G17630.1; AT3G17630.1; AT3G17630.
DR EnsemblPlants; AT3G17630.2; AT3G17630.2; AT3G17630.
DR GeneID; 821030; -.
DR Gramene; AT3G17630.1; AT3G17630.1; AT3G17630.
DR Gramene; AT3G17630.2; AT3G17630.2; AT3G17630.
DR KEGG; ath:AT3G17630; -.
DR Araport; AT3G17630; -.
DR TAIR; locus:2090462; AT3G17630.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_2_1; -.
DR InParanoid; Q9LUN4; -.
DR OMA; MDGHMES; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q9LUN4; -.
DR PRO; PR:Q9LUN4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LUN4; baseline and differential.
DR Genevisible; Q9LUN4; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; IDA:TAIR.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IMP:TAIR.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..800
FT /note="Cation/H(+) antiporter 19"
FT /id="PRO_0000394989"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 776..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 800 AA; 86915 MW; E152F0A604E3781E CRC64;
MASTNVTGQC PGPMKATSNG AFQNESPLDF ALPLIILQIV LVVVFTRLLA YFLKPLKQPR
VIAEIIGGIL LGPSALGRSK AYLDTIFPKK SLTVLDTLAN IGLLFFLFLV GLELDFAAIK
KTGKKSLLIA IAGISLPFIV GVGTSFVLSA TISKGVDQLP FIVFMGVALS ITAFPVLARI
LAELKLLTTD IGRMAMSAAG VNDVAAWILL ALAIALSGDG TSPLVSVWVL LCGTGFVIFA
VVAIKPLLAY MARRCPEGEP VKELYVCVTL TVVLAASFVT DTIGIHALFG AFVVGIVAPK
EGPFCRILTE KIEDLVSGLL LPLYFAASGL KTDVTTIRGA QSWGLLVLVI LTTCFGKIVG
TVGSSMLCKV PFREAVTLGF LMNTKGLVEL IVLNIGKDRK VLNDQAFAIL VLMALFTTFI
TTPIVMLIYK PARKGAPYKH RTIQRKDHDS ELRILACFHS TRNIPTLINL IESSRGTGKK
GRLCVYAMHL MELSERSSAI AMVHKARNNG LPIWNKIERS TDQMVIAFEA YQHLRAVAVR
PMTAISGLSS IHEDICTSAH QKRVAMILLP FHKHQRMDGA MESIGHRFHE VNQRVLQRAP
CSVGILVDRG LGGTSQVVAS EVAYKVVIPF FGGLDDREAL AYGMKMVEHP GITLTVYKFV
AARGTLKRFE KSEHDEKEKK EKETDEEFVR ELMNDPRGNE SLAYEERVVE SKDDIIATLK
SMSKCNLFVV GRNAAVASLV KSTDCPELGP VGRLLSSSEF STTASVLVVQ GYDPAADTRP
LVEEDAEYDQ SSRDISDLTA
