CHX1_ARATH
ID CHX1_ARATH Reviewed; 785 AA.
AC Q9SA37;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Cation/H(+) antiporter 1;
DE AltName: Full=Protein CATION/H+ EXCHANGER 1;
DE Short=AtCHX1;
GN Name=CHX1; Synonyms=CHX01; OrderedLocusNames=At1g16380; ORFNames=F3O9.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC TISSUE=Pollen;
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in pollen.
CC {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
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DR EMBL; AY926465; AAX49537.1; -; mRNA.
DR EMBL; AC006341; AAD34690.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29444.1; -; Genomic_DNA.
DR PIR; A86299; A86299.
DR RefSeq; NP_173088.1; NM_101504.2.
DR AlphaFoldDB; Q9SA37; -.
DR BioGRID; 23448; 3.
DR IntAct; Q9SA37; 3.
DR STRING; 3702.AT1G16380.1; -.
DR TCDB; 2.A.37.4.7; the monovalent cation:proton antiporter-2 (cpa2) family.
DR iPTMnet; Q9SA37; -.
DR PaxDb; Q9SA37; -.
DR PRIDE; Q9SA37; -.
DR ProteomicsDB; 246918; -.
DR EnsemblPlants; AT1G16380.1; AT1G16380.1; AT1G16380.
DR GeneID; 838208; -.
DR Gramene; AT1G16380.1; AT1G16380.1; AT1G16380.
DR KEGG; ath:AT1G16380; -.
DR Araport; AT1G16380; -.
DR TAIR; locus:2032805; AT1G16380.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_2_1; -.
DR InParanoid; Q9SA37; -.
DR OMA; KMLWEND; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q9SA37; -.
DR PRO; PR:Q9SA37; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SA37; baseline and differential.
DR Genevisible; Q9SA37; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..785
FT /note="Cation/H(+) antiporter 1"
FT /id="PRO_0000394971"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 785 AA; 88909 MW; 3830426AAA66CB1C CRC64;
MDPKMLFCLP EGDALFNPLN TMFIQMACIL VFSQFFYLFL KPCGQAGPVA QILAGIVLSL
LTIIRKVHEF FLQKDSASYY IFFSFLLRTA FVFLIGLEID LDFMKRNLKN SIVITLGSLV
ISGIIWLPFL WFLIRFMQIK GDFLTFYLAF LITLSNTAAP VVIRSIIDWK LHTSEIGRLA
ISCGLFIEIT NIFIYTIVLS FISGTMTADI FIYSFATGVI ILTNRFLASW LPKRNPKEKY
LSKAETLAFI ILILIIALTI ESSNLNSTLF VFIIGLMFPR EGKTYRTLIQ RLSYPIHEFV
LPVYFGYIGF RFSVNSLTKR HYLVLGMTVA LSLLGKLLGV LFACSFLKIP KQYWLFLSTM
LSVKGHIGLV LLDSNLMYKK WFTPVVHDMF VAALVIMTLL SGVITSLLLR SQEKSFAHIK
TSLELFDTTE ELRVLTCVYG VRHARGSISL VSALSGFSPG TSSSPFTPYL MHLIPLPKKR
KTELLYHELD EDAGNSNGGD DEFGTNEGLE INDSIDSFTR DRKIMVRQVK LVAPMENMHE
EICNATEDLR VSIVFLPFHK HQRIDGKTTN DGEVFRHMNR KVLKQAQCSI GIFVDRNITG
FHQLHGSDSV QHVAALFFGG PDDREALSLC KWLTNNSQIH LTVIQFVADD SKTEKIVGDA
VTKENNEVFL EIVSEDQTEN ETDRIFLEEF YHRFVTTGQV GFIEKRVSNG MQTLTILREI
GEMYSLFVVG KNRGDCPMTS GMNDWEECPE LGTVGDFLAS SNMDVNASVL VVQRHRNSFD
SFVDE
