CHX24_ARATH
ID CHX24_ARATH Reviewed; 859 AA.
AC Q1HDT2; Q9FHW1;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Cation/H(+) antiporter 24;
DE AltName: Full=Protein CATION/H+ EXCHANGER 24;
DE Short=AtCHX24;
GN Name=CHX24; OrderedLocusNames=At5g37060; ORFNames=MJG14.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT clones.";
RL DNA Res. 6:183-195(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-856, TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC TISSUE=Pollen;
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in pollen.
CC {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11358.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB017068; BAB11358.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED94143.1; -; Genomic_DNA.
DR EMBL; DQ499022; ABF54932.1; -; mRNA.
DR RefSeq; NP_198522.1; NM_123065.2.
DR AlphaFoldDB; Q1HDT2; -.
DR SMR; Q1HDT2; -.
DR BioGRID; 18928; 14.
DR IntAct; Q1HDT2; 14.
DR STRING; 3702.AT5G37060.1; -.
DR SwissPalm; Q1HDT2; -.
DR PaxDb; Q1HDT2; -.
DR PRIDE; Q1HDT2; -.
DR ProteomicsDB; 246883; -.
DR EnsemblPlants; AT5G37060.1; AT5G37060.1; AT5G37060.
DR GeneID; 833677; -.
DR Gramene; AT5G37060.1; AT5G37060.1; AT5G37060.
DR KEGG; ath:AT5G37060; -.
DR Araport; AT5G37060; -.
DR TAIR; locus:2166168; AT5G37060.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_2_1; -.
DR InParanoid; Q1HDT2; -.
DR OMA; PYMVNKR; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q1HDT2; -.
DR PRO; PR:Q1HDT2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q1HDT2; baseline and differential.
DR Genevisible; Q1HDT2; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Phosphoprotein; Potassium;
KW Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..859
FT /note="Cation/H(+) antiporter 24"
FT /id="PRO_0000394993"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..458
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 538..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 857
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9SUQ7"
SQ SEQUENCE 859 AA; 96681 MW; 7379EA46F92741FE CRC64;
MVRHFPINDQ SLLPAHFGFW PGNSTTPGEV SNRVFSPKIP VVCRKLHSKQ PFGMFKGENA
MNYAFSTFLI EAIIIIFFIK VVSIALRPFR QPRIVSEIIG GMMIGPSMFG GIRNFNYYLF
PPIANYICAN IGLMGFFYFL FLTAAKTDVG AIGKAPRKHK YIAAIGVIVP IICVGSVGMA
MRDQMDENLQ KPSSIGGVVF ALSFTSFPVI YTVLRDMNLL NSEVGKFAMS VALLGDMAGV
YVIVIFEAMT HADVGGAYSV FWFLVSVVIF AAFMLLVVRR AFDWIVSQTP EGTLVNQNYI
VMILMGVLAS CFLTDMFGLS IAVGPIWLGL LVPHGPPLGS TLAVRSETFI YEFLMPFTYA
LVGQGTNIHF LRDETWRNQL SPLFYMTVVG FITKFLSTAF AALFFKVPAR ESITLGLMMN
LRGQMDLLVY LHWIDKRIVG FPGYTVMVLH TVVVTAVTTP LINFFYDPTR PYRSSKHRTI
QHTPQNTEMG LVLAVSDHET LSGLITFLDF AYPTKSSPLS IFAVQLVELA GRATPLFIDH
EQRKEEEEEE YEEEEEEPER KQSGRIDQVQ SAFKLYEEKR NECVTLRSYT AHAPKRLMYQ
DICELALGKK TAFILLPYQK ERLEDAAPTE LRDSGMLSVN ADVLEHTPCS VCIYFDKGRL
KNAVVRLSMD LQHSTNSIRM RQETYRFVVL FLGGADNREA LHLADRMSTN PDVTLTVIRF
LSYNHEGEDE REKKLDDGVV TWFWVKNESN ERVSYKEVVV KNGAETLAAI QAMNVNDYDL
WITGRREGIN PKILEGLSTW SEDHQLGVIG DTVAASVFAS EGSVLVVQQQ VRNQKGGDGF
LNGKFDYKRF LSPWSHSHN
