CHX25_ARATH
ID CHX25_ARATH Reviewed; 857 AA.
AC Q9FGH6;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Cation/H(+) antiporter 25;
DE AltName: Full=Protein CATION/H+ EXCHANGER 25;
DE Short=AtCHX25;
GN Name=CHX25; OrderedLocusNames=At5g58460; ORFNames=MQJ2.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in pollen.
CC {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
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DR EMBL; AB025632; BAB10261.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97055.1; -; Genomic_DNA.
DR RefSeq; NP_200654.1; NM_125232.2.
DR AlphaFoldDB; Q9FGH6; -.
DR SMR; Q9FGH6; -.
DR STRING; 3702.AT5G58460.1; -.
DR PaxDb; Q9FGH6; -.
DR PRIDE; Q9FGH6; -.
DR ProteomicsDB; 246972; -.
DR EnsemblPlants; AT5G58460.1; AT5G58460.1; AT5G58460.
DR GeneID; 835959; -.
DR Gramene; AT5G58460.1; AT5G58460.1; AT5G58460.
DR KEGG; ath:AT5G58460; -.
DR Araport; AT5G58460; -.
DR TAIR; locus:2171238; AT5G58460.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_2_1; -.
DR InParanoid; Q9FGH6; -.
DR OMA; NYICANL; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q9FGH6; -.
DR PRO; PR:Q9FGH6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FGH6; baseline and differential.
DR Genevisible; Q9FGH6; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Phosphoprotein; Potassium;
KW Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..857
FT /note="Cation/H(+) antiporter 25"
FT /id="PRO_0000394994"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 855
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9SUQ7"
SQ SEQUENCE 857 AA; 95833 MW; 5EA87F54AC2EEE73 CRC64;
MVRSFPSDGW SALPTRFGFW PENPTTAGVV SSRVFSARLP EVCRQVHDKQ PFGMFKGENG
MNYTFSTFLI EAILIIFFIK IVYVLLRPLR QPRIVCEIIG GMMIGPSMLG RNRNFNYYLF
PPIANYICAN IGLMGFFYFF FLTAAKTDVA EIFKAPRKHK YIAAVSVLVP IACVGSTGAA
LKHKMDIRLQ KPSSIGGVTF ALGFTSFPVI YTVLRDMNLL NSEIGKFAMS VTLLGDMVGV
YVLVLFEAMA QADGGGGAYS VIWFLISAAI MAACLLLVVK RSFEWIVAKT PEGGLVNQNY
IVNILMGVLV SCFLTDMFGM AIAVGPIWLG LVVPHGPPLG STLAIRSETF VNEFLMPFSF
ALVGQKTNVN LISKETWPKQ ISPLIYMSIV GFVTKFVSST GAALFFKVPT RDSLTLGLMM
NLRGQIDILL YLHWIDKQMV GLPGYSVMVL YAIVVTGVTA PLISFLYDPT RPYRSSKRRT
IQHTPQNTET GLVLAVTDHD TFSGLITFLD FAYPTKTSPF SVFAIQLVEL EGRAQPLFIA
HDKKREEEYE EEEEPAERMG SRRVDQVQSA FKLYQEKRSE CVTMHAYTAH ASKHNMYQNI
CELALTKKTA FILLPYQKER LQDAALTELR DSGMLSVNAD VLAHTPCSVC IYYEKGRLKN
AMVRSSMDPQ HTTNSSHMRQ EMYRFVVLFL GGADNREALH LADRMTENPF INLTVIRFLA
HNHEGEDERE KKLDDGVVTW FWVKNESNAR VSYKEVVVKN GAETLAAIQA MNVNDYDLWI
TGRREGINPK ILEGLSTWSE DHQLGVIGDT VAGSVFASEG SVLVVQQQVR NQMGGDGFLN
GKFDYKKLVS PWSHSHN
