CHX26_ARATH
ID CHX26_ARATH Reviewed; 784 AA.
AC Q9M008;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Cation/H(+) antiporter 26;
DE AltName: Full=Protein CATION/H+ EXCHANGER 26;
DE Short=AtCHX26;
GN Name=CHX26; OrderedLocusNames=At5g01680; ORFNames=F7A7_200;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in pollen. {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB82284.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL161946; CAB82284.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED90376.1; -; Genomic_DNA.
DR PIR; T48189; T48189.
DR RefSeq; NP_195788.2; NM_120246.2.
DR AlphaFoldDB; Q9M008; -.
DR SMR; Q9M008; -.
DR TCDB; 2.A.37.4.6; the monovalent cation:proton antiporter-2 (cpa2) family.
DR PaxDb; Q9M008; -.
DR PRIDE; Q9M008; -.
DR EnsemblPlants; AT5G01680.1; AT5G01680.1; AT5G01680.
DR GeneID; 831698; -.
DR Gramene; AT5G01680.1; AT5G01680.1; AT5G01680.
DR KEGG; ath:AT5G01680; -.
DR Araport; AT5G01680; -.
DR TAIR; locus:2149740; AT5G01680.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_1_1; -.
DR InParanoid; Q9M008; -.
DR OMA; SIMVANC; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q9M008; -.
DR PRO; PR:Q9M008; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9M008; baseline and differential.
DR Genevisible; Q9M008; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..784
FT /note="Cation/H(+) antiporter 26"
FT /id="PRO_0000394995"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 784 AA; 87038 MW; CE76C7FD89F6BB9B CRC64;
MNNSVTSNGT HEFVCEAWLG SSSGGLLRGD DPLKYSTPLL LLLISLVSSL SSVFQALLRP
LANVDFVTQI LAGIFLGPSA LGQNIDLVKK LFNTRSYFII ESFEAISFMF ISYISTAQVD
MGVIKRGGKL AIINGLSLFL FPYVVGAIAC TVITSNIRGT VAKNNPEQLH NLLTNQSVVY
FQVAYSVLSN LKMLNSEPGR LALSSIMVAN CFGWGFFLLL ITFDSFLHQN YSKTTYLPTF
TKVLLLVGIV VVCRPIFNWI VKRTPEGKKL KASHLCTICV MLCTATFLSE TVGFPYVVGS
VALGLVTPKT PPFGTGLTDK IGSFCYAVLM PCYVIGIGNK VDFFSFNLRD IISLEFLIFT
ISAAKFASIV LPSLYFQVPI SHAVIVGFIV CIQGIYDVQI FKQLLNYKNI SHEAFGIMVI
SAMVHSTIFT AIVKNLYGWV QRKHITYRRQ TVQHYEPNKP LKILTCFYHR ETVPPILTVL
ELSTCPSSAS SHSIVSVNLE ELEQNNVPLL IQHHPGHNDE SSTSSSRRDQ ISKAFEKFRS
GHDLQENVSV ECFTAVAPSK TMHEDVCALA FEKETDLIIF GMADGTAAER RLCRNVRNAS
PSSVAVLMDQ GRLPDFKNMG TAMKNGSMRI NICSIFLGGA DDRETLAFAV RMTNQPYVNL
TVLKLVDGEN VSHLNDVVEK RLDFRTIEKF RQDTMNKHNV ALREVWIKEA SDLVNLLREE
GNNYDLIMVG IRHEKSFEVL QGLSVWSEIE ELGEIGDLLV SRDLKLSASV LAVQQQLSSV
VEEV
