CHX4_ARATH
ID CHX4_ARATH Reviewed; 817 AA.
AC Q9FYC1;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Cation/H(+) antiporter 4;
DE AltName: Full=Protein CATION/H+ EXCHANGER 4;
DE Short=AtCHX4;
GN Name=CHX4; Synonyms=CHX04; OrderedLocusNames=At3g44900; ORFNames=F28D10.90;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC TISSUE=Pollen;
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
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DR EMBL; DQ499020; ABF54930.1; -; mRNA.
DR EMBL; AL391254; CAC03540.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77966.1; -; Genomic_DNA.
DR PIR; T51787; T51787.
DR RefSeq; NP_190076.1; NM_114359.2.
DR AlphaFoldDB; Q9FYC1; -.
DR SMR; Q9FYC1; -.
DR BioGRID; 8944; 1.
DR STRING; 3702.AT3G44900.1; -.
DR PaxDb; Q9FYC1; -.
DR PRIDE; Q9FYC1; -.
DR EnsemblPlants; AT3G44900.1; AT3G44900.1; AT3G44900.
DR GeneID; 823624; -.
DR Gramene; AT3G44900.1; AT3G44900.1; AT3G44900.
DR KEGG; ath:AT3G44900; -.
DR Araport; AT3G44900; -.
DR TAIR; locus:2082142; AT3G44900.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_1_1; -.
DR InParanoid; Q9FYC1; -.
DR OMA; DIRPMIN; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q9FYC1; -.
DR PRO; PR:Q9FYC1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9FYC1; baseline and differential.
DR Genevisible; Q9FYC1; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..817
FT /note="Cation/H(+) antiporter 4"
FT /id="PRO_0000394974"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 817 AA; 92008 MW; 653B4491E36558FC CRC64;
MEFNGDRIPY LRDTWRDANM ICGILPINPS SSGLWPSPKL PDPQANIEFW NYMFPHVQII
FLIVTILWQF FHFFLRRLGM IRFTSHMLTG ILLSKSFLKE NTPARKFLST EDYKETLFGL
VGACSYMMFW FLMGVKMDLS LIRSTGRKAV AIGLSSVLLS ITVCALIFFL ILRDVGTKKG
EPVMSFFEII FIYLIQCLSS FPVIGNLLFE LRLQNSELGR LAMSSAVISD FSTSILSAVL
VFLKELKDDK SRLGSVFIGD VIVGNRPMKR AGTVVLFVCF AIYIFRPLMF FIIKRTPSGR
PVKKFYIYAI IILVFGSAIL ADWCKQSIFI GPFILGLAVP HGPPLGSAIL QKFESVVFGT
FLPFFVATSA EEIDTSILQS WIDLKSIVIL VSVSFIVKFA LTTLPAFLYG MPAKDCIALS
LIMSFKGIFE FGAYGYAYQR GTIRPVTFTV LSLYILLNSA VIPPLLKRIY DPSRMYAGYE
KRNMLHMKPN SELRILSCIY KTDDIRPMIN LLEATCPSRE NPVATYVLHL MELVGQANPV
LISHRLQTRK SENMSYNSEN VVVSFEQFHN DFFGSVFVST YTALSVPKMM HGDICMLALN
NTTSLIILPF HQTWSADGSA IVSDSLMIRQ LNKSVLDLSP CSVGIFVYRS SNGRRTIKET
AANFSSYQVC MLFLGGKDDR EALSLAKRMA RDSRITITVV SLISSEQRAN QATDWDRMLD
LELLRDVKSN VLAGADIVFS EEVVNDANQT SQLLKSIANE YDLFIVGREK GRKSVFTEGL
EEWSEFEELG IIGDLLTSQD LNCQASVLVI QQQQQMI
