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CHX5_ARATH
ID   CHX5_ARATH              Reviewed;         815 AA.
AC   Q3EDG3; Q9LMZ3; Q9SGE4;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Cation/H(+) antiporter 5;
DE   AltName: Full=Protein CATION/H+ EXCHANGER 5;
DE            Short=AtCHX5;
GN   Name=CHX5; Synonyms=CHX05; OrderedLocusNames=At1g08150;
GN   ORFNames=T23G18.2, T6D22.24;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA   Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA   Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA   Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT   "Phylogenetic relationships within cation transporter families of
RT   Arabidopsis.";
RL   Plant Physiol. 126:1646-1667(2001).
RN   [4]
RP   TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=15347787; DOI=10.1104/pp.104.046003;
RA   Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA   Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT   "Expression patterns of a novel AtCHX gene family highlight potential roles
RT   in osmotic adjustment and K+ homeostasis in pollen development.";
RL   Plant Physiol. 136:2532-2547(2004).
CC   -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Preferentially expressed in pollen.
CC       {ECO:0000269|PubMed:15347787}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF18257.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 4 genes: At1g08135, At1g08140, At1g08150 and At1g08160.; Evidence={ECO:0000305};
CC       Sequence=AAF79832.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 4 genes: At1g08135, At1g08140, At1g08150 and At1g08160.; Evidence={ECO:0000305};
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DR   EMBL; AC011438; AAF18257.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC026875; AAF79832.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE28254.1; -; Genomic_DNA.
DR   PIR; A86216; A86216.
DR   RefSeq; NP_172294.2; NM_100690.3.
DR   AlphaFoldDB; Q3EDG3; -.
DR   SMR; Q3EDG3; -.
DR   STRING; 3702.AT1G08150.1; -.
DR   iPTMnet; Q3EDG3; -.
DR   PaxDb; Q3EDG3; -.
DR   PRIDE; Q3EDG3; -.
DR   EnsemblPlants; AT1G08150.1; AT1G08150.1; AT1G08150.
DR   GeneID; 837336; -.
DR   Gramene; AT1G08150.1; AT1G08150.1; AT1G08150.
DR   KEGG; ath:AT1G08150; -.
DR   Araport; AT1G08150; -.
DR   TAIR; locus:2205165; AT1G08150.
DR   eggNOG; KOG1650; Eukaryota.
DR   HOGENOM; CLU_005126_6_1_1; -.
DR   OMA; GIVELCY; -.
DR   OrthoDB; 336706at2759; -.
DR   PhylomeDB; Q3EDG3; -.
DR   PRO; PR:Q3EDG3; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q3EDG3; baseline and differential.
DR   GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   2: Evidence at transcript level;
KW   Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..815
FT                   /note="Cation/H(+) antiporter 5"
FT                   /id="PRO_0000394975"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   815 AA;  91606 MW;  B0BB888C5634279E CRC64;
     MESRNEAYEG AYNATFWGDF SYHGYGFSED GSKFCEQIPI LVNSFGVWEK LDLPIRGMKI
     WDYSLPHLES VIVLVLCLWQ FFYLSLKKIG LPVPKITSMM IAGAALSQTN LLPNDWTIQH
     ILFPDDTRPK VPETLGGFAF VFYWFIEGVK MDVGMVRKTG TKVIVTGIAT VILPIIAANM
     VFGKLRETGG KYLTGMEYRT ILFMQSISAF TGISRLLRDL RINHSEFGRI VISTAMVADG
     TGFGVNLFAL VAWMDWRVSA LQGVGIIGYV IFMVWVVRPA MFWVIKRTPQ ERPVKECFIY
     IILILAFGGY YFLKEIHMFP AVGPFLLGLC VPHGPPLGSQ LVEKFESFNT GILLPLFLFF
     SMLQIDGPWL ANQIGQLRHF DGQLYEALTI IIVVFVAKII FSMIPALLAK MPLTDSFVMA
     LILSNKGIVE LCYFLYGVES NVLHVKSFTI MATMILVSST ISPVLIHYLY DSSKRFISFQ
     KRNLMSLKLG SELKFLVCIH KADHISGMIN LLAQSFPLHE STISCYVIHL VELVGLDNPV
     FISHQMQKAE PGNRSYSNNV LIAFDNFKHY WKSISLELFT CISNPRYMHQ EIYSLALDKQ
     ASFLMLPFHI IWSLDQTTVV SDDVMRRNAN LNVLRQAPCS VGIFVHRQKL LSAQKSSPSF
     EVCAIFVGGK DDREALALGR QMMRNPNVNL TVLKLIPAKM DGMTTGWDQM LDSAEVKEVL
     RNNNNTVGQH SFVEYVEETV NDGSDTSTLL LSIANSFDLF VVGRSAGVGT DVVSALSEWT
     EFDELGVIGD LLVSQDFPRR GSVLVVQQQQ NVACR
 
 
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