CHX5_ARATH
ID CHX5_ARATH Reviewed; 815 AA.
AC Q3EDG3; Q9LMZ3; Q9SGE4;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Cation/H(+) antiporter 5;
DE AltName: Full=Protein CATION/H+ EXCHANGER 5;
DE Short=AtCHX5;
GN Name=CHX5; Synonyms=CHX05; OrderedLocusNames=At1g08150;
GN ORFNames=T23G18.2, T6D22.24;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in pollen.
CC {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF18257.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 4 genes: At1g08135, At1g08140, At1g08150 and At1g08160.; Evidence={ECO:0000305};
CC Sequence=AAF79832.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 4 genes: At1g08135, At1g08140, At1g08150 and At1g08160.; Evidence={ECO:0000305};
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DR EMBL; AC011438; AAF18257.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC026875; AAF79832.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28254.1; -; Genomic_DNA.
DR PIR; A86216; A86216.
DR RefSeq; NP_172294.2; NM_100690.3.
DR AlphaFoldDB; Q3EDG3; -.
DR SMR; Q3EDG3; -.
DR STRING; 3702.AT1G08150.1; -.
DR iPTMnet; Q3EDG3; -.
DR PaxDb; Q3EDG3; -.
DR PRIDE; Q3EDG3; -.
DR EnsemblPlants; AT1G08150.1; AT1G08150.1; AT1G08150.
DR GeneID; 837336; -.
DR Gramene; AT1G08150.1; AT1G08150.1; AT1G08150.
DR KEGG; ath:AT1G08150; -.
DR Araport; AT1G08150; -.
DR TAIR; locus:2205165; AT1G08150.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_1_1; -.
DR OMA; GIVELCY; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q3EDG3; -.
DR PRO; PR:Q3EDG3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q3EDG3; baseline and differential.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..815
FT /note="Cation/H(+) antiporter 5"
FT /id="PRO_0000394975"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 815 AA; 91606 MW; B0BB888C5634279E CRC64;
MESRNEAYEG AYNATFWGDF SYHGYGFSED GSKFCEQIPI LVNSFGVWEK LDLPIRGMKI
WDYSLPHLES VIVLVLCLWQ FFYLSLKKIG LPVPKITSMM IAGAALSQTN LLPNDWTIQH
ILFPDDTRPK VPETLGGFAF VFYWFIEGVK MDVGMVRKTG TKVIVTGIAT VILPIIAANM
VFGKLRETGG KYLTGMEYRT ILFMQSISAF TGISRLLRDL RINHSEFGRI VISTAMVADG
TGFGVNLFAL VAWMDWRVSA LQGVGIIGYV IFMVWVVRPA MFWVIKRTPQ ERPVKECFIY
IILILAFGGY YFLKEIHMFP AVGPFLLGLC VPHGPPLGSQ LVEKFESFNT GILLPLFLFF
SMLQIDGPWL ANQIGQLRHF DGQLYEALTI IIVVFVAKII FSMIPALLAK MPLTDSFVMA
LILSNKGIVE LCYFLYGVES NVLHVKSFTI MATMILVSST ISPVLIHYLY DSSKRFISFQ
KRNLMSLKLG SELKFLVCIH KADHISGMIN LLAQSFPLHE STISCYVIHL VELVGLDNPV
FISHQMQKAE PGNRSYSNNV LIAFDNFKHY WKSISLELFT CISNPRYMHQ EIYSLALDKQ
ASFLMLPFHI IWSLDQTTVV SDDVMRRNAN LNVLRQAPCS VGIFVHRQKL LSAQKSSPSF
EVCAIFVGGK DDREALALGR QMMRNPNVNL TVLKLIPAKM DGMTTGWDQM LDSAEVKEVL
RNNNNTVGQH SFVEYVEETV NDGSDTSTLL LSIANSFDLF VVGRSAGVGT DVVSALSEWT
EFDELGVIGD LLVSQDFPRR GSVLVVQQQQ NVACR