CHX6B_ARATH
ID CHX6B_ARATH Reviewed; 796 AA.
AC P0CG16; Q9LMZ3; Q9SGE4;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Cation/H(+) antiporter 6B;
DE AltName: Full=Protein CATION/H+ EXCHANGER 6b;
DE Short=AtCHX6b;
GN Name=CHX6b; Synonyms=CHX06b; OrderedLocusNames=At1g08135;
GN ORFNames=T23G18.2, T6D22.24;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [4]
RP TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in pollen.
CC {ECO:0000269|PubMed:15347787}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF18257.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 4 genes: At1g08135, At1g08140, At1g08150 and At1g08160.; Evidence={ECO:0000305};
CC Sequence=AAF79832.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 4 genes: At1g08135, At1g08140, At1g08150 and At1g08160.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC011438; AAF18257.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC026875; AAF79832.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28252.1; -; Genomic_DNA.
DR PIR; A86216; A86216.
DR RefSeq; NP_849610.2; NM_179279.3.
DR AlphaFoldDB; P0CG16; -.
DR SMR; P0CG16; -.
DR STRING; 3702.AT1G08135.1; -.
DR PaxDb; P0CG16; -.
DR PRIDE; P0CG16; -.
DR ProteomicsDB; 246976; -.
DR EnsemblPlants; AT1G08135.1; AT1G08135.1; AT1G08135.
DR GeneID; 837334; -.
DR Gramene; AT1G08135.1; AT1G08135.1; AT1G08135.
DR KEGG; ath:AT1G08135; -.
DR Araport; AT1G08135; -.
DR TAIR; locus:1005716662; AT1G08135.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_1_1; -.
DR OMA; KALESPC; -.
DR OrthoDB; 336706at2759; -.
DR PRO; PR:P0CG16; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; P0CG16; baseline and differential.
DR Genevisible; P0CG16; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..796
FT /note="Cation/H(+) antiporter 6B"
FT /id="PRO_0000394977"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 796 AA; 90112 MW; 70BC4BF08B69042C CRC64;
MDAENATWRK EFMWNNDEKR AEMGTKMFCD VSPHIMLNSH GVAEKMASGS KGMDFWEYPL
PQLEIIILSI FLLWRLFDML FKKLGVPIPK FTSMMLVGAV LSEMFGSMQI PCLKHIFIHY
NQYMTKVPDT IGAFAFVLDW FLRGVTTDVG IMKKSGTKSV VIGITSMIIP WQIGKLLYSS
REKSSILTMT EMEYTVMTFT MSMTPFTCVN MLLTDLKIVH TDFGQIAQSA GMVTDLLAFF
LTVSAYVSRD ETQGVKMGLA FMAFFIFVYL VRQFMLWVIR HTPEGAPVKN VYLYIGLLLA
YLSYLYWSRF LFFGPLGAFA LGLAVPNGPP LGSVFIQKFD SFNEGIFLPL FGSLSMIKLD
WSFLRKEFGN GRHLHGHMYE CFSFLPIVYI AKFATSFLAA LATKIPLRDS IILGVIMGTK
SSFELGYVLT AFEKDRISLE VLSLLGVYIL VNSLLTPMAI HFLYDRSKRF VCYGRRNLKE
KPEMQTLVCI NKPDNITSMI SLLRATSPSK DSPMECCVLH LIELLGQATP TFISHQLQKP
KPGSRSYSEN VISSFQLFQE VYWDSASINM FTSLTSAKEM HEQICWFALS QGSNLILLSF
HRTWEPNGNV IISDDQTLRS LNLNVLKRAP CSVGIFVYRK PIWQTKALES PCRVCLIYVG
GNDDKEALAL ADHMRGNQQV ILTVLRLIPT SYADESSLRI HSQMVDMNRH EDQRPGDKST
IIDWTVGDGT ETSKILHSVS YDYDLFIVGR RSGVGTTVTR GLGDWMEFEE LGVIGDLLAS
EYFPSRASVL VVQQQE
