CHX9_ARATH
ID CHX9_ARATH Reviewed; 800 AA.
AC Q9FFB7; Q58P70;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Cation/H(+) antiporter 9;
DE AltName: Full=Protein CATION/H+ EXCHANGER 9;
DE Short=AtCHX9;
GN Name=CHX9; Synonyms=CHX09; OrderedLocusNames=At5g22910; ORFNames=MRN17.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-789, GENE FAMILY, AND NOMENCLATURE.
RC TISSUE=Pollen;
RX PubMed=15347787; DOI=10.1104/pp.104.046003;
RA Sze H., Padmanaban S., Cellier F., Honys D., Cheng N.-H., Bock K.W.,
RA Conejero G., Li X., Twell D., Ward J.M., Hirschi K.D.;
RT "Expression patterns of a novel AtCHX gene family highlight potential roles
RT in osmotic adjustment and K+ homeostasis in pollen development.";
RL Plant Physiol. 136:2532-2547(2004).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: May operate as a cation/H(+) antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000305}.
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DR EMBL; AB005243; BAB10612.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93096.1; -; Genomic_DNA.
DR EMBL; AY926469; AAX49541.1; -; mRNA.
DR RefSeq; NP_197682.1; NM_122197.1.
DR AlphaFoldDB; Q9FFB7; -.
DR SMR; Q9FFB7; -.
DR BioGRID; 17630; 14.
DR IntAct; Q9FFB7; 10.
DR STRING; 3702.AT5G22910.1; -.
DR PaxDb; Q9FFB7; -.
DR PRIDE; Q9FFB7; -.
DR EnsemblPlants; AT5G22910.1; AT5G22910.1; AT5G22910.
DR GeneID; 832355; -.
DR Gramene; AT5G22910.1; AT5G22910.1; AT5G22910.
DR KEGG; ath:AT5G22910; -.
DR Araport; AT5G22910; -.
DR TAIR; locus:2172646; AT5G22910.
DR eggNOG; KOG1650; Eukaryota.
DR HOGENOM; CLU_005126_6_1_1; -.
DR InParanoid; Q9FFB7; -.
DR OMA; LIFCELP; -.
DR OrthoDB; 336706at2759; -.
DR PhylomeDB; Q9FFB7; -.
DR PRO; PR:Q9FFB7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FFB7; differential.
DR Genevisible; Q9FFB7; AT.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..800
FT /note="Cation/H(+) antiporter 9"
FT /id="PRO_0000394980"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 800 AA; 89060 MW; 37EFBF207997F3EB CRC64;
MTDSQALVPG PSPPHSKAEI CYGATFFNIS SYGIMEKYET PTVIFGYALP LLELQIILIF
VCIVLSHMFL RRIGIPRFVS NILAGLILGP QLLDLLEYSS DRLSLDIPGN VALEGVARLG
LVMFTFLMGV KTNKRAVYQI GKRPIVIAVS SFFVTMISGL AFRNFRLDKV DPLYMPLRLA
PTERSVIVSI QAVTLLPVIT HLVYELKMSN SELGRIAIST AAVSDFLGFL TLVCISYVGT
YRYVSPGIAN RDIVALIILV LVILFIFKPM AQRIVDMTPE GKPVPKVYLY VTILTAIAAS
IYLSVFNQMY ILGALLVGLA IPDGPPLGSA LEARFESLVT NIFFPISIAV MAMKADVVRA
LYSFDDISFN ILLLGLTVVV KWTASFVPCL IFCELPTRES VIIATIMNYK GFVDLCFFDV
ALRRRNLSRA TYTVMIIYVL LNAGILPTII KALYDPKRKY IGYVKRDIMH LKTNSDLKIL
TCLHKPDNIS GAISLLELLS SPLNNDNKDR GVIAVTALHL VKLAGRTFPI LIPHDKRSKA
RLLQNSYIQT MMLAFTEFQQ ENWESTTVSS FTAYSHENLM DQDICNLALD HLTSMIIVPS
GRKWSPDGEY ESDDIMIRRV NESLLDLAPC SVGILNYRGY NKGKKKTNSI INVGVIFIGG
KDDREALSLA KWMGQNSRVC LTVIRFLSGQ ELDKSKNWDY LVDDEVLNDL KATYSLANNF
NYMEKVVNGG PAVATTVRLV AEDHDLMIVG RDHEDYSLDL TGLAQWMELP ELGVIGDLLA
SKDLRARVSV LVVQQQQQHG
