ID   CHYM_FELCA              Reviewed;          54 AA.
AC   P09873;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Chymosin;
DE            EC=3.4.23.4;
DE   Flags: Precursor; Fragment;
GN   Name=CYM;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6810938; DOI=10.1016/0167-4838(82)90185-6;
RA   Jensen T., Axelsen N.H., Foltmann B.;
RT   "Isolation and partial characterization of prochymosin and chymosin from
RT   cat.";
RL   Biochim. Biophys. Acta 705:249-256(1982).
CC   -!- FUNCTION: Chymosin is synthesized in the mucosa of the stomach. The
CC       enzyme hydrolyzes casein to paracasein.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Broad specificity similar to that of pepsin A. Clots milk by
CC         cleavage of a single 104-Ser-Phe-|-Met-Ala-107 bond in kappa-chain of
CC         casein.; EC=3.4.23.4;
CC   -!- SUBUNIT: Monomer.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family. {ECO:0000305}.
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DR   PIR; A20146; A20146.
DR   MEROPS; A01.041; -.
DR   InParanoid; P09873; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; PTHR47966; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   SUPFAM; SSF50630; SSF50630; 1.
PE   1: Evidence at protein level;
KW   Aspartyl protease; Digestion; Direct protein sequencing; Hydrolase;
KW   Protease; Reference proteome; Zymogen.
FT   PROPEP          1..27
FT                   /note="Activation peptide"
FT                   /id="PRO_0000025992"
FT   CHAIN           28..>54
FT                   /note="Chymosin"
FT                   /evidence="ECO:0000269|PubMed:6810938"
FT                   /id="PRO_0000025993"
FT   NON_TER         54
SQ   SEQUENCE   54 AA;  6129 MW;  0E7D7DA3AC2AC474 CRC64;
     SEITRVPLHK GKSLRKALKE HGLLEBFDKV SNEPLADFLD SEYFGKIYIG TPPZ