CHZ1_ASHGO
ID CHZ1_ASHGO Reviewed; 140 AA.
AC Q755T5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Histone H2A.Z-specific chaperone CHZ1;
GN Name=CHZ1; OrderedLocusNames=AER433W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Forms a chaperone-bound H2A.Z-H2B complex that acts as a
CC source for SWR1 complex-dependent H2A to H2A.Z histone replacement in
CC chromatin. {ECO:0000250}.
CC -!- SUBUNIT: Forms a heterotrimer with H2A.Z-H2B, stabilizing the
CC association of the histone dimer. Also, with a lower affinity, forms a
CC heterotrimer with H2A-H2B (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CHZ1 family. {ECO:0000305}.
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DR EMBL; AE016818; AAS53112.1; -; Genomic_DNA.
DR RefSeq; NP_985288.1; NM_210642.1.
DR AlphaFoldDB; Q755T5; -.
DR SMR; Q755T5; -.
DR STRING; 33169.AAS53112; -.
DR EnsemblFungi; AAS53112; AAS53112; AGOS_AER433W.
DR GeneID; 4621508; -.
DR KEGG; ago:AGOS_AER433W; -.
DR eggNOG; ENOG502SCUM; Eukaryota.
DR HOGENOM; CLU_126134_1_0_1; -.
DR InParanoid; Q755T5; -.
DR OMA; RRNYDDY; -.
DR Proteomes; UP000000591; Chromosome V.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042393; F:histone binding; IEA:EnsemblFungi.
DR GO; GO:0006338; P:chromatin remodeling; IEA:EnsemblFungi.
DR InterPro; IPR019098; Histone_chaperone_domain_CHZ.
DR Pfam; PF09649; CHZ; 1.
DR SMART; SM01082; CHZ; 1.
PE 3: Inferred from homology;
KW Chaperone; Nucleus; Reference proteome.
FT CHAIN 1..140
FT /note="Histone H2A.Z-specific chaperone CHZ1"
FT /id="PRO_0000330198"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..140
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 140 AA; 15084 MW; B90E8F58115F6B0C CRC64;
MAEKAAEKAE QRAADEAEKR PVEDGEKHSG RKRRRRNYDE HDEAVAKDDA QSAKAGAAAD
SDADDSDADD EKLEVLMARE EEDEDDLAEI DASNIISGGR RTRGKVIDYK QTAEELAAEG
AAAGVDDDAE DADADFDGEG
