CIA30_CAEBR
ID CIA30_CAEBR Reviewed; 340 AA.
AC Q61FQ3; A8XCR5;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Probable complex I intermediate-associated protein 30, mitochondrial;
DE AltName: Full=NADH ubiquinone oxidoreductase assembly factor 1;
DE Flags: Precursor;
GN Name=nuaf-1; ORFNames=CBG11538;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Chaperone protein involved in the assembly of the
CC mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
CC Required for normal growth and reproduction (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CIA30 family. {ECO:0000305}.
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DR EMBL; HE600908; CAP30433.1; -; Genomic_DNA.
DR RefSeq; XP_002635291.1; XM_002635245.1.
DR AlphaFoldDB; Q61FQ3; -.
DR SMR; Q61FQ3; -.
DR STRING; 6238.CBG11538; -.
DR PRIDE; Q61FQ3; -.
DR EnsemblMetazoa; CBG11538.1; CBG11538.1; WBGene00032645.
DR GeneID; 8577287; -.
DR KEGG; cbr:CBG_11538; -.
DR CTD; 8577287; -.
DR WormBase; CBG11538; CBP02779; WBGene00032645; Cbr-nuaf-1.
DR eggNOG; KOG2435; Eukaryota.
DR HOGENOM; CLU_059028_2_2_1; -.
DR InParanoid; Q61FQ3; -.
DR OMA; SMKLEDR; -.
DR OrthoDB; 1563319at2759; -.
DR Proteomes; UP000008549; Chromosome V.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IBA:GO_Central.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IBA:GO_Central.
DR GO; GO:0010257; P:NADH dehydrogenase complex assembly; IBA:GO_Central.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR013857; NADH-UbQ_OxRdtase-assoc_prot30.
DR InterPro; IPR039131; NDUFAF1.
DR PANTHER; PTHR13194; PTHR13194; 1.
DR Pfam; PF08547; CIA30; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
PE 3: Inferred from homology;
KW Chaperone; Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..340
FT /note="Probable complex I intermediate-associated protein
FT 30, mitochondrial"
FT /id="PRO_0000251471"
SQ SEQUENCE 340 AA; 38816 MW; FCE1CC63F9194013 CRC64;
MISNFTGRLL LPKFRNKLCA FFSKESTSSN SLAKSKTNSE LEGYTGKSNL LEKKKVGVFG
TSTVPINTNF PNPKGVIGYD PDFSVKELVA ELPNTRKTQG AKLAEEIKDA FSNISIEKPE
LLEDIGFVRH NEARVEYKFD TSEKLDLWKI GCDSDWKEGF STCSLVNSDR GTAVFSGNIS
TRVLKDGRVE RAGWASMKLE DRKTFNRKKF LSKWRNFSHL LLKVRGDGRS YKIMLHSPLS
MDFTWGDSFS HPLHTHGGPY WQYEKIPFSK FFHTVAGRIQ DRQYRVNLED TSSIGIVLMD
RIDGDFKLEI DYIGVYNDTT HVEDFAYETY TLPVFNTHGF