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CIA30_DROME
ID   CIA30_DROME             Reviewed;         296 AA.
AC   Q9VAI1;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Complex I intermediate-associated protein 30, mitochondrial {ECO:0000312|FlyBase:FBgn0039689};
DE   Flags: Precursor;
GN   Name=CIA30 {ECO:0000312|FlyBase:FBgn0039689};
GN   ORFNames=CG7598 {ECO:0000312|FlyBase:FBgn0039689};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Ovary;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=23226344; DOI=10.1371/journal.pone.0050644;
RA   Cho J., Hur J.H., Graniel J., Benzer S., Walker D.W.;
RT   "Expression of yeast NDI1 rescues a Drosophila complex I assembly defect.";
RL   PLoS ONE 7:E50644-E50644(2012).
CC   -!- FUNCTION: Chaperone protein involved in the assembly of the
CC       mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
CC       {ECO:0000269|PubMed:23226344}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Larvae are viable but most do not survive the
CC       late pupa/early adult stages. Surviving adults that are assisted to
CC       eclose display severe degeneration of myofibrils and mitochondria.
CC       {ECO:0000269|PubMed:23226344}.
CC   -!- SIMILARITY: Belongs to the CIA30 family. {ECO:0000305}.
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DR   EMBL; AE014297; AAF56928.1; -; Genomic_DNA.
DR   EMBL; AY060912; AAL28460.1; -; mRNA.
DR   RefSeq; NP_651718.1; NM_143461.4.
DR   AlphaFoldDB; Q9VAI1; -.
DR   SMR; Q9VAI1; -.
DR   BioGRID; 68367; 1.
DR   IntAct; Q9VAI1; 1.
DR   STRING; 7227.FBpp0084839; -.
DR   PaxDb; Q9VAI1; -.
DR   PRIDE; Q9VAI1; -.
DR   DNASU; 43503; -.
DR   EnsemblMetazoa; FBtr0085473; FBpp0084839; FBgn0039689.
DR   GeneID; 43503; -.
DR   KEGG; dme:Dmel_CG7598; -.
DR   UCSC; CG7598-RA; d. melanogaster.
DR   CTD; 100034914; -.
DR   FlyBase; FBgn0039689; CIA30.
DR   VEuPathDB; VectorBase:FBgn0039689; -.
DR   eggNOG; KOG2435; Eukaryota.
DR   GeneTree; ENSGT00390000007200; -.
DR   HOGENOM; CLU_059028_2_2_1; -.
DR   InParanoid; Q9VAI1; -.
DR   OMA; TFWEREK; -.
DR   OrthoDB; 1563319at2759; -.
DR   PhylomeDB; Q9VAI1; -.
DR   Reactome; R-DME-6799198; Complex I biogenesis.
DR   BioGRID-ORCS; 43503; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 43503; -.
DR   PRO; PR:Q9VAI1; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0039689; Expressed in Malpighian tubule and 11 other tissues.
DR   ExpressionAtlas; Q9VAI1; baseline and differential.
DR   Genevisible; Q9VAI1; DM.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:1990204; C:oxidoreductase complex; ISS:UniProtKB.
DR   GO; GO:0051082; F:unfolded protein binding; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IMP:FlyBase.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:FlyBase.
DR   GO; GO:0007005; P:mitochondrion organization; IMP:FlyBase.
DR   GO; GO:0010257; P:NADH dehydrogenase complex assembly; IBA:GO_Central.
DR   GO; GO:0009408; P:response to heat; IMP:FlyBase.
DR   GO; GO:0055093; P:response to hyperoxia; IMP:FlyBase.
DR   GO; GO:0001666; P:response to hypoxia; IMP:FlyBase.
DR   GO; GO:0042594; P:response to starvation; IMP:FlyBase.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR013857; NADH-UbQ_OxRdtase-assoc_prot30.
DR   InterPro; IPR039131; NDUFAF1.
DR   PANTHER; PTHR13194; PTHR13194; 1.
DR   Pfam; PF08547; CIA30; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..29
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..296
FT                   /note="Complex I intermediate-associated protein 30,
FT                   mitochondrial"
FT                   /id="PRO_0000005467"
SQ   SEQUENCE   296 AA;  34206 MW;  A7E3B06898731DB3 CRC64;
     MNSLLRQGLR LGCCLPAVQQ QIHTTAVHRT FWEREKKSGY KTKLPEPSKK QMIMDGLRDL
     KEEMKLWRQE VKEQFESDPI LVFRPGETDV VFDFKAPDVL DKWTVTTDAD HGEGKSTATL
     ELSAAGAGLF HGQVNSDHTK DGIIKRTGYA NIRTKRVRKS FKRETTYDWT QYNMLVMKVR
     GDGRSYLINL HTEGYFDLMW NDIYHYVLYT RGGPHWQIAK IPFSKFFLSS KGRVQDRQGA
     IPLNRVTHFG FSVAAKKGMD GPFGLEIDYV GLEYDPSHRE EFAYEMYQTP KYIVAT
 
 
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