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CIA30_NEUCR
ID   CIA30_NEUCR             Reviewed;         278 AA.
AC   O42636; Q7SE85;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Complex I intermediate-associated protein 30, mitochondrial;
DE   Flags: Precursor;
GN   Name=cia30; Synonyms=cia35; ORFNames=B13D15.210, NCU01975;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, FUNCTION, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=9769214; DOI=10.1006/jmbi.1998.2114;
RA   Kueffner R., Rohr A., Schmiede A., Kruell C., Schulte U.;
RT   "Involvement of two novel chaperones in the assembly of mitochondrial
RT   NADH:ubiquinone oxidoreductase (complex 1).";
RL   J. Mol. Biol. 283:409-417(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Chaperone protein involved in the assembly of the
CC       mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
CC       {ECO:0000269|PubMed:9769214}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:9769214}.
CC   -!- SIMILARITY: Belongs to the CIA30 family. {ECO:0000305}.
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DR   EMBL; AJ001726; CAA04954.1; -; Genomic_DNA.
DR   EMBL; BX842630; CAE76376.1; -; Genomic_DNA.
DR   EMBL; CM002236; EAA35103.3; -; Genomic_DNA.
DR   PIR; T47247; T47247.
DR   RefSeq; XP_964339.3; XM_959246.3.
DR   AlphaFoldDB; O42636; -.
DR   STRING; 367110.O42636; -.
DR   PRIDE; O42636; -.
DR   EnsemblFungi; EAA35103; EAA35103; NCU01975.
DR   GeneID; 3880479; -.
DR   KEGG; ncr:NCU01975; -.
DR   VEuPathDB; FungiDB:NCU01975; -.
DR   HOGENOM; CLU_059028_1_2_1; -.
DR   InParanoid; O42636; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:1990204; C:oxidoreductase complex; IDA:UniProtKB.
DR   GO; GO:0051082; F:unfolded protein binding; IDA:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IDA:UniProtKB.
DR   GO; GO:0010257; P:NADH dehydrogenase complex assembly; IBA:GO_Central.
DR   GO; GO:0065003; P:protein-containing complex assembly; NAS:UniProtKB.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR013857; NADH-UbQ_OxRdtase-assoc_prot30.
DR   InterPro; IPR039131; NDUFAF1.
DR   PANTHER; PTHR13194; PTHR13194; 1.
DR   Pfam; PF08547; CIA30; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Direct protein sequencing; Mitochondrion; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..8
FT                   /note="Mitochondrion"
FT   CHAIN           9..278
FT                   /note="Complex I intermediate-associated protein 30,
FT                   mitochondrial"
FT                   /id="PRO_0000005468"
SQ   SEQUENCE   278 AA;  31181 MW;  7A960789F982BCFB CRC64;
     MRATQSLPFK SFWSRSLDEL SRLTNIVVKS ENIRGATGPR EIHNFQTPES VADCKLLSDA
     DVGGSSTAHL DWVPPPNAIP TVTAGDGSDR KPYTPIPGSY ARFHGTISLE LPTDRREISR
     TGYAGFRTLD RPPTIFGRGL WDIDPYAYLA MRVKTDARSY FVNVRTESVV PLDLHQHRLF
     VKKPGQWETV LIKWNDFVRT NHGKVIEPQT GMLRQKVLSI GFSTTDRKAG PYELCVERLW
     ATNDFDEAGV VETDVAGAQL KNKHGEKVKV TWGALEQE
 
 
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