ID   CIA30_PANTR             Reviewed;         327 AA.
AC   Q0MQ84;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   23-FEB-2022, entry version 56.
DE   RecName: Full=Complex I intermediate-associated protein 30, mitochondrial {ECO:0000250|UniProtKB:Q9Y375};
DE   AltName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1;
DE   Flags: Precursor;
GN   Name=NDUFAF1 {ECO:0000250|UniProtKB:Q9Y375};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA   Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B.,
RA   Wallace D.C.;
RT   "Adaptive selection of mitochondrial complex I subunits during primate
RT   radiation.";
RL   Gene 378:11-18(2006).
CC   -!- FUNCTION: As part of the MCIA complex, involved in the assembly of the
CC       mitochondrial complex I. {ECO:0000250|UniProtKB:Q9Y375}.
CC   -!- SUBUNIT: Part of the mitochondrial complex I assembly/MCIA complex that
CC       comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9
CC       and complement subunits such as COA1 and TMEM186. Interacts with ECSIT.
CC       Interacts with ACAD9. At early stages of complex I assembly, it is
CC       found in intermediate subcomplexes that contain different subunits
CC       including NDUFB6, NDUFA6, NDUFA9, NDUFS3, NDUFS7, ND1, ND2 and ND3.
CC       Interacts with TMEM70 and TMEM242 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y375}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9Y375}.
CC       Mitochondrion matrix {ECO:0000250|UniProtKB:Q9Y375}. Note=Periferally
CC       associated with the matrix face of the mitochondrial inner membrane.
CC       {ECO:0000250|UniProtKB:Q9Y375}.
CC   -!- SIMILARITY: Belongs to the CIA30 family. {ECO:0000305}.
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DR   EMBL; DQ885750; ABH12259.1; -; mRNA.
DR   RefSeq; NP_001073392.1; NM_001079923.1.
DR   STRING; 9598.ENSPTRP00000011848; -.
DR   PaxDb; Q0MQ84; -.
DR   GeneID; 739838; -.
DR   KEGG; ptr:739838; -.
DR   CTD; 51103; -.
DR   eggNOG; KOG2435; Eukaryota.
DR   InParanoid; Q0MQ84; -.
DR   OrthoDB; 1563319at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IBA:GO_Central.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   GO; GO:0010257; P:NADH dehydrogenase complex assembly; IBA:GO_Central.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR013857; NADH-UbQ_OxRdtase-assoc_prot30.
DR   InterPro; IPR039131; NDUFAF1.
DR   PANTHER; PTHR13194; PTHR13194; 1.
DR   Pfam; PF08547; CIA30; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Mitochondrion; Phosphoprotein; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..24
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..327
FT                   /note="Complex I intermediate-associated protein 30,
FT                   mitochondrial"
FT                   /id="PRO_0000251469"
FT   REGION          43..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         318
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y375"
SQ   SEQUENCE   327 AA;  37830 MW;  B8D40B7A77BC16AB CRC64;
     MALVHKLLRG TYFLRKFXKP TSALYPFLGI RFAEYSSSLQ KPVASPGKAS SQRKTEGDLQ
     GDHQKEVALD ITSSEEKPDV SFDKAIRDEA MYHFRHLKDE IVDHWRGPEG HPLHEVLLEQ
     AKVVWQFRGK EDLDKWTVTS DKTIGGRSEV FLKMGKNNQS ALLYGTLSSE APQDGESTRS
     GYCAMISRIP RGAFERKMSY DWSQFNTLYL RVRGDGRPWM VNIKEDTDFF QRTNQMYSYF
     MFTRGGPYWQ EVKIPFSKFF FSNRGRIRDV QHELPLDKIS SIGFTLADKV DGPFFLEIDF
     IGVFTDPAHT EEFAYENSPE LNPRLFK