ID   CIA84_NEUCR             Reviewed;         797 AA.
AC   O42637; Q7S820; Q872A6;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Complex I intermediate-associated protein 84, mitochondrial;
DE   Flags: Precursor;
GN   Name=cia84; Synonyms=cia80; ORFNames=B11O8.100, NCU01006;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, FUNCTION, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=9769214; DOI=10.1006/jmbi.1998.2114;
RA   Kueffner R., Rohr A., Schmiede A., Kruell C., Schulte U.;
RT   "Involvement of two novel chaperones in the assembly of mitochondrial
RT   NADH:ubiquinone oxidoreductase (complex 1).";
RL   J. Mol. Biol. 283:409-417(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Chaperone protein involved in the assembly of the
CC       mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
CC       {ECO:0000269|PubMed:9769214}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:9769214}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA04945.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=EAA32382.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AJ001712; CAA04945.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; BX294014; CAD70828.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA32382.3; ALT_SEQ; Genomic_DNA.
DR   PIR; T47250; T47250.
DR   RefSeq; XP_961618.3; XM_956525.3.
DR   AlphaFoldDB; O42637; -.
DR   STRING; 5141.EFNCRP00000004252; -.
DR   EnsemblFungi; EAA32382; EAA32382; NCU01006.
DR   GeneID; 3877825; -.
DR   KEGG; ncr:NCU01006; -.
DR   HOGENOM; CLU_019319_0_0_1; -.
DR   InParanoid; O42637; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
PE   1: Evidence at protein level;
KW   Chaperone; Direct protein sequencing; Mitochondrion; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..69
FT                   /note="Mitochondrion"
FT   CHAIN           70..797
FT                   /note="Complex I intermediate-associated protein 84,
FT                   mitochondrial"
FT                   /id="PRO_0000020929"
FT   CONFLICT        106..110
FT                   /note="RPPPR -> LPTST (in Ref. 1; CAA04945)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        749
FT                   /note="A -> P (in Ref. 1; CAA04945)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   797 AA;  91821 MW;  409C8DF345810EDB CRC64;
     MRSHLARNAT TTTPNVYRRL HAAVGHHHGL LRPCSATALS ARRCLFDCQH DVAHIPRDVA
     LCTRTSKRTF ISLFTPKPER FVKLPHFDPG YNVLLQYRKS EVEQERPPPR DQLVTAFKKL
     TKFKADTNRP LNPNQAFLLR TVLHYLLVTK PEADAPVDLK MSDLENAMDA ALLPPKGSPE
     FHLALARLLH EEIMRRRLIL LNPEERKVHL TKDDFARYIK ALTQYGGSLE AAGRVKEFWQ
     QLKDERSAVY FRGSGRIWIM VLEGLANEGR EEELLQFWEE AQETGGIKYI PGVHQIFVTY
     YARQDKIEET KQWYSKPIHS GFSPTGETLL ELVRSSRRSS QKWNEWLLPV FEQVVQDKFA
     KKGSLDAFLQ WSVLALDKGP DGIKTYLQTM ASGDFYQSHE VKVDATTINR LMQAAQEKGN
     PYMAERFWQL AQDFNIKANV HTYLNQMSYR LDANDIEGAH QIFSKLASGA VEVEFDEDLP
     VMNKYLRVLC AQQEPNIQHI LTITSALEQR HAVLEPETIV ALCLVFLNHD KKFDVIDTLS
     LHSVSISHIE RQQIYKAFVD YICSPQTTTD RAWDAYSLLR QYFPETSVDD RVRLMESFFE
     RKKPDMACLV FGHMRAHDDD NMHPTADIYV RCLEGLGRCP IPEQRPSDPA SSLKMVHNML
     KMDTRVEMNT RLYNALMLAY AAGGDPFTAL DFWEEHITRS AEGPSYNSLA IVFWCCELIP
     LGDRYARPVW QKMLRMDLEV PQLGLTYNAL PDPVSKDEFA AWAKEEYPEE WARLESKGQK
     ETEFQGPVFN ITRLFEA