ID   CIAO1_AEDAE             Reviewed;         337 AA.
AC   Q17GR9;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=AAEL002912;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; CH477256; EAT45868.1; -; Genomic_DNA.
DR   RefSeq; XP_001662680.1; XM_001662630.1.
DR   AlphaFoldDB; Q17GR9; -.
DR   SMR; Q17GR9; -.
DR   STRING; 7159.AAEL002912-PA; -.
DR   GeneID; 5576487; -.
DR   KEGG; aag:5576487; -.
DR   VEuPathDB; VectorBase:AAEL002912; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; Q17GR9; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   PhylomeDB; Q17GR9; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..337
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein Ciao1"
FT                   /id="PRO_0000382480"
FT   REPEAT          12..51
FT                   /note="WD 1"
FT   REPEAT          58..97
FT                   /note="WD 2"
FT   REPEAT          102..141
FT                   /note="WD 3"
FT   REPEAT          147..186
FT                   /note="WD 4"
FT   REPEAT          193..232
FT                   /note="WD 5"
FT   REPEAT          251..290
FT                   /note="WD 6"
FT   REPEAT          301..337
FT                   /note="WD 7"
SQ   SEQUENCE   337 AA;  37538 MW;  0B3255EEB698E751 CRC64;
     MGKLELLQCL TGHRGRAWGA GWHPKGNVLA TCGEDKTIRI WAEDASQRWV AKTVLSDGHS
     RTIRDVAWSP CGQYLASASF DATVAIWDKK SGEFECNATL EGHENEVKSV SWSKSGSLLA
     TCSRDKSVWV WEVAQEDEYE CAAVLNTHTQ DVKKVEWHPH EDILASASYD NTIKLYKEDL
     ADSDWSSFDT LVSHESTVWS ISFDGSGNRL ASCSDDQTVK IWQEYKPGNE FGVSCPDNTP
     VWKCVCTLAG YHSRSVYDIS WCKQSGLLAT ACGDDMVRIF KEVEGSSPHE PTFEMVGSKH
     AHSQDVNTVE WNPTVVGLLV TTSDDGDVKL WKYEPEE