ID   CIAO1_ANOGA             Reviewed;         341 AA.
AC   Q7PS24;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 3.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=AGAP000444;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; AAAB01008846; EAA06279.4; -; Genomic_DNA.
DR   RefSeq; XP_310648.3; XM_310648.5.
DR   AlphaFoldDB; Q7PS24; -.
DR   SMR; Q7PS24; -.
DR   STRING; 7165.AGAP000444-PA; -.
DR   PaxDb; Q7PS24; -.
DR   GeneID; 1271794; -.
DR   KEGG; aga:AgaP_AGAP000444; -.
DR   CTD; 1271794; -.
DR   VEuPathDB; VectorBase:AGAP000444; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; Q7PS24; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   PhylomeDB; Q7PS24; -.
DR   Proteomes; UP000007062; Chromosome X.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..341
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein Ciao1"
FT                   /id="PRO_0000382481"
FT   REPEAT          12..51
FT                   /note="WD 1"
FT   REPEAT          58..97
FT                   /note="WD 2"
FT   REPEAT          102..141
FT                   /note="WD 3"
FT   REPEAT          151..190
FT                   /note="WD 4"
FT   REPEAT          197..236
FT                   /note="WD 5"
FT   REPEAT          255..294
FT                   /note="WD 6"
FT   REPEAT          305..341
FT                   /note="WD 7"
SQ   SEQUENCE   341 AA;  38235 MW;  1E387CF5D598CB30 CRC64;
     MGKLELLQTL TGHAGRVWSA AWHPGGKLFA SCGEDKTIRV WNKSDTDRWV AQTVLTDGHT
     RTIRELAWSC CGHYLASASF DTTVAVWDKK SGEFECNATL EGHDNEVKSV TWSRSGNLLA
     TCSRDKSVWI WEIHHAPDQE DEYECVAVLN GHTQDVKKVC WHPQEDLLAS ASYDNTIRMY
     RQDLADSEWE MLEPLESHSS TVWSISFDAT GQRLASCSED TTVKVWQQYG PDNALGIPCP
     DRGTIWKCVC TLSGYHSRSV YDIDWCKQTG LLATACGDDT VRIFREASDS DRNEPTFELV
     VTVEAHSQDA NKVAWHPTVP GLLLTASDDG EIKLWQYVDA D