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CIAO1_ASHGO
ID   CIAO1_ASHGO             Reviewed;         328 AA.
AC   Q75C26;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037}; OrderedLocusNames=ACR091W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBUNIT: Interacts with NAR1. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03037}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03037}. Note=Preferentially
CC       localized to the nucleus. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; AE016816; AAS51317.1; -; Genomic_DNA.
DR   RefSeq; NP_983493.1; NM_208846.1.
DR   AlphaFoldDB; Q75C26; -.
DR   SMR; Q75C26; -.
DR   STRING; 33169.AAS51317; -.
DR   EnsemblFungi; AAS51317; AAS51317; AGOS_ACR091W.
DR   GeneID; 4619620; -.
DR   KEGG; ago:AGOS_ACR091W; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; Q75C26; -.
DR   OMA; DDWECAA; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:EnsemblFungi.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..328
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382499"
FT   REPEAT          12..49
FT                   /note="WD 1"
FT   REPEAT          54..93
FT                   /note="WD 2"
FT   REPEAT          102..141
FT                   /note="WD 3"
FT   REPEAT          148..187
FT                   /note="WD 4"
FT   REPEAT          192..233
FT                   /note="WD 5"
FT   REPEAT          246..284
FT                   /note="WD 6"
FT   REPEAT          291..328
FT                   /note="WD 7"
SQ   SEQUENCE   328 AA;  36661 MW;  216F36650B8A63A1 CRC64;
     MPNLHLVRSL KLHGDRCWSV DISKGLLATG SADRKIKLVD VRNFKLVEEL DDTAHKKAVR
     SVAWRPHCNV LAAGSFDTTV SIWGRDDDDY SGETELLAVI EGHENEVKSV AWSHDGAYLA
     TCSRDKSVWI WEADELSEEF ECNSVLQEHS QDVKHIVWHA SRLLLASSSY DDTVRIWAEQ
     DDDWECAAVL SGHGGTVWCS DFERAETGIR LCSGSDDTTV RIWRCLTDDA DVFDKEWIQE
     TVLPAVHTRA VYSVSWSADG LIASVGSDGV LAVYKEVQAG RWEVVARVDC AHTVYEINVV
     KWLALDGRVL LVTGGDDGCV NVWELREE
 
 
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