ID   CIAO1_ASPCL             Reviewed;         453 AA.
AC   A1CQL6;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=cia1; ORFNames=ACLA_026540;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; DS027059; EAW07937.1; -; Genomic_DNA.
DR   RefSeq; XP_001269363.1; XM_001269362.1.
DR   AlphaFoldDB; A1CQL6; -.
DR   SMR; A1CQL6; -.
DR   STRING; 5057.CADACLAP00002530; -.
DR   EnsemblFungi; EAW07937; EAW07937; ACLA_026540.
DR   GeneID; 4700989; -.
DR   KEGG; act:ACLA_026540; -.
DR   VEuPathDB; FungiDB:ACLA_026540; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..453
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382500"
FT   REPEAT          15..57
FT                   /note="WD 1"
FT   REPEAT          61..103
FT                   /note="WD 2"
FT   REPEAT          153..192
FT                   /note="WD 3"
FT   REPEAT          200..239
FT                   /note="WD 4"
FT   REPEAT          244..305
FT                   /note="WD 5"
FT   REPEAT          338..377
FT                   /note="WD 6"
FT   REPEAT          409..450
FT                   /note="WD 7"
FT   REGION          107..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  49308 MW;  E07AE8EFAFC22513 CRC64;
     MAAEPTARLS LLSDLTPPSL ERTWLTAPHP TLPIVATCSS DKTVRVYSLT NFRLLSTISG
     GHKRSVRTCA WKPHVKGESV LATGSFDATV GIWRRWDSYG QTERGAADWG VGDSAGSGTQ
     AKGLADGYGA GGDEENENED EDEEWRFAVL LDGHDSEVKS VSWSPSGMLL ATCSRDKSIW
     IWEDLDDGDN NFETVAVMQE HQGDVKCVAW HPAEDCLASA SYDDTIRLWR EDLDDWGQVA
     CIKGHQGTVW CVDWEGVDSV PCGAAADLAE QWRATHALSG PRLVSCSDDR TVRIWRRQPK
     EPRAQQNTSP FGSSGIPSII RPTGTDETWE EECTLPQAHD LSVYTVAWSK RTGLLASVGA
     DGRIVVYAER FVGGDSATQA METEPSADAA EGAPAPSTEW TVIATMDGAH DIYEINHVAW
     AKRADRGKAE GEDEEVLVTT ADDGGVKVWT IAR