ID   CIAO1_ASPFN             Reviewed;         438 AA.
AC   B8MWR8;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=cia1; ORFNames=AFLA_088680;
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS   / JCM 12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=332952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC   167;
RX   PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; EQ963472; EED58169.1; -; Genomic_DNA.
DR   RefSeq; XP_002373781.1; XM_002373740.1.
DR   AlphaFoldDB; B8MWR8; -.
DR   SMR; B8MWR8; -.
DR   STRING; 5059.CADAFLAP00001646; -.
DR   EnsemblFungi; EED58169; EED58169; AFLA_088680.
DR   VEuPathDB; FungiDB:AFLA_088680; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   OMA; AIWSKSS; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Repeat; WD repeat.
FT   CHAIN           1..438
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382502"
FT   REPEAT          15..57
FT                   /note="WD 1"
FT   REPEAT          61..103
FT                   /note="WD 2"
FT   REPEAT          140..179
FT                   /note="WD 3"
FT   REPEAT          187..226
FT                   /note="WD 4"
FT   REPEAT          254..297
FT                   /note="WD 5"
FT   REPEAT          327..366
FT                   /note="WD 6"
FT   REPEAT          396..438
FT                   /note="WD 7"
FT   REGION          290..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        296..310
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   438 AA;  48857 MW;  5FC3E603AF02C840 CRC64;
     MTENPTASLT LLSDLTPPSL ERTWLTAPHP SLPIVATCSS DKTVRVYSLT NFRLLSTISG
     GHKRSVRTCA WKPHVQGESV LATGSFDATV GIWRRWDSYG RAEDGTDVRG LSSETLDGNG
     RDTQEYEDDE EWRFAVLLDG HDSEVKSVSW SPSGMLLATC SRDKSIWIWE DLDDGDNNFE
     TVAVMQEHEG DVKCVAWHPV EECLASASYD NTIRLWREDI DDWGQVACIK GHTGTVWYLD
     WEGIGNVPST AAVCEQGTSL SAEWKDQRAM SGPRLASCSD DRTVRIWKRR PKEQRAQSQV
     GSTGIPSIIR PTGTDETWEE DVLLPQIHEL SIYAVAWSKR TGLLASVGAD GRIVVYEELF
     LTSPARTPDT NTPTDTSAII PRTHTEWVAI AILEGAHGIY EVNHVAWARR ADRCRKENEE
     VLITTADDGS IKVWTLRR