CIAO1_ASPFU
ID CIAO1_ASPFU Reviewed; 460 AA.
AC Q4WTL0;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN Name=cia1; ORFNames=AFUA_1G08930;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC protein assembly machinery. Required for the maturation of
CC extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC Rule:MF_03037}.
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DR EMBL; AAHF01000004; EAL90222.1; -; Genomic_DNA.
DR RefSeq; XP_752260.1; XM_747167.1.
DR AlphaFoldDB; Q4WTL0; -.
DR SMR; Q4WTL0; -.
DR STRING; 746128.CADAFUBP00000819; -.
DR EnsemblFungi; EAL90222; EAL90222; AFUA_1G08930.
DR GeneID; 3510478; -.
DR KEGG; afm:AFUA_1G08930; -.
DR VEuPathDB; FungiDB:Afu1g08930; -.
DR eggNOG; KOG0645; Eukaryota.
DR HOGENOM; CLU_000288_57_8_1; -.
DR InParanoid; Q4WTL0; -.
DR OMA; AIWSKSS; -.
DR OrthoDB; 793298at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03037; ciao1; 1.
DR InterPro; IPR028608; CIAO1/Cia1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19920; PTHR19920; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..460
FT /note="Probable cytosolic iron-sulfur protein assembly
FT protein 1"
FT /id="PRO_0000382503"
FT REPEAT 17..59
FT /note="WD 1"
FT REPEAT 63..105
FT /note="WD 2"
FT REPEAT 151..190
FT /note="WD 3"
FT REPEAT 198..237
FT /note="WD 4"
FT REPEAT 242..308
FT /note="WD 5"
FT REPEAT 342..381
FT /note="WD 6"
FT REPEAT 416..457
FT /note="WD 7"
FT REGION 301..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 50653 MW; 7DF8D36912653791 CRC64;
MVMAAEASSQ LSLLSDLTPP SLERTWLTAP HPTLPIVATC SSDKTVRVYS LTNFRLLSTI
SGGHKRSVRT CAWKPHVKGE SVLATGSFDA TVGIWRRWDS YGQTERGIED WRHADSHDHV
DGMGAAGINN GGGDSADEDD EEWRFAVLLD GHDSEVKSVS WSPSGMLLAT CSRDKSIWIW
EDLDDGDNNF ETVAVMQEHQ GDVKCVAWHP VEECLASASY DDTIRLWRED LDDWGQVACI
KGHQGTVWCV DWEGAENVPS APTDLADDDP VTAQWKKAHA LSGPRLVSCS DDRTVRIWRR
QPKEQHQHQA QPSPSGGSGI PSIIRPTGSD EFWDEECVLP QAHDLSIYTV AWSKRTGLIA
SVGADGRVVV YEERFIVGST AEAMETDHPT SADGTAADSP AALRTEWRVI ATVDGAHGIY
EINHVTWAKR ADRGRIEGTD EEVLITTADD GTVRVWTLKM