ID   CIAO1_ASPNC             Reviewed;         412 AA.
AC   A2QPW4;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=cia1; ORFNames=An08g00420;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; AM270157; CAK45194.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2QPW4; -.
DR   SMR; A2QPW4; -.
DR   PaxDb; A2QPW4; -.
DR   EnsemblFungi; CAK45194; CAK45194; An08g00420.
DR   VEuPathDB; FungiDB:An08g00420; -.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   Proteomes; UP000006706; Chromosome 8R.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..412
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382504"
FT   REPEAT          20..62
FT                   /note="WD 1"
FT   REPEAT          66..108
FT                   /note="WD 2"
FT   REPEAT          165..204
FT                   /note="WD 3"
FT   REPEAT          212..255
FT                   /note="WD 4"
FT   REPEAT          257..291
FT                   /note="WD 5"
FT   REPEAT          318..357
FT                   /note="WD 6"
FT   REPEAT          367..407
FT                   /note="WD 7"
FT   REGION          108..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..144
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   412 AA;  45764 MW;  C8BE4B152D0FD865 CRC64;
     MAAVDHPASS LPHLQLLSDL TPPSLERTWL TAPHPRLPIV ATCSSDKTVR VYSLTNFRLL
     STISGGHKRS VRTAAWKPHV QGESVLATGS FDATAGIWRR WDSYGQTTGD EGWGLGQETT
     TNKSESQEEQ AQETDILRQQ QATHNENDGA DDEDEEWRFA VLLDGHDSEV KSVSWSPSGM
     LLATCSRDKS IWIWEDLDDG DNNFETVAVM QEHEGDVKCV AWHPVEECLA SASYDDTIRI
     WREDLDDWGQ VACLRGHEGT VWFLSGPRIV SCSDDRTVRV WRRQPKEQAA AGGTGMPSIL
     RPTGLDETWE EETVLPKVHD LAVYAVAWSK RTGLLASVGA DGRIVIYEER LGVVRTEWVI
     LAVLPGAHGI YEINHVAWAN RADRDRDVSK EEEVLVTTAD DGSVKVDETV GL