CIAO1_BOVIN
ID CIAO1_BOVIN Reviewed; 339 AA.
AC Q32PJ6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 {ECO:0000255|HAMAP-Rule:MF_03037};
DE AltName: Full=WD repeat-containing protein 39 {ECO:0000255|HAMAP-Rule:MF_03037};
GN Name=CIAO1 {ECO:0000255|HAMAP-Rule:MF_03037}; Synonyms=WDR39;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into extramitochondrial Fe/S proteins (By
CC similarity). As a CIA complex component, interacts specifically with
CC CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur
CC protein assembly, depending of its interactors. The complex
CC CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most
CC cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1
CC and stabilizes IREB2 (By similarity). Seems to specifically modulate
CC the transactivation activity of WT1. As part of the mitotic spindle-
CC associated MMXD complex it may play a role in chromosome segregation
CC (By similarity). {ECO:0000250|UniProtKB:O76071, ECO:0000255|HAMAP-
CC Rule:MF_03037}.
CC -!- SUBUNIT: Component of the CIA complex. Interacts with CIAO2A and forms
CC a complex with CIAO2B and MMS19; the interactions with CIAO2A and
CC CIAO2B are mutually exclusive. Interacts with CHD1L, ERCC2, IREB2 and
CC POLD1. Component of the MMXD complex, which includes CIAO1, ERCC2,
CC CIAO2B, MMS19 and SLC25A5. Interacts with WT1. Interacts with CIAO3.
CC Interacts (via LYR motif) with HSC20. {ECO:0000250|UniProtKB:O76071,
CC ECO:0000255|HAMAP-Rule:MF_03037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O76071}.
CC -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC Rule:MF_03037}.
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DR EMBL; BC108091; AAI08092.1; -; mRNA.
DR RefSeq; NP_001032559.1; NM_001037482.2.
DR AlphaFoldDB; Q32PJ6; -.
DR SMR; Q32PJ6; -.
DR STRING; 9913.ENSBTAP00000020797; -.
DR PaxDb; Q32PJ6; -.
DR PRIDE; Q32PJ6; -.
DR Ensembl; ENSBTAT00000020797; ENSBTAP00000020797; ENSBTAG00000015659.
DR GeneID; 540069; -.
DR KEGG; bta:540069; -.
DR CTD; 9391; -.
DR VEuPathDB; HostDB:ENSBTAG00000015659; -.
DR VGNC; VGNC:27356; CIAO1.
DR eggNOG; KOG0645; Eukaryota.
DR GeneTree; ENSGT00940000158670; -.
DR HOGENOM; CLU_000288_57_8_1; -.
DR InParanoid; Q32PJ6; -.
DR OMA; AIWSKSS; -.
DR OrthoDB; 793298at2759; -.
DR TreeFam; TF318181; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000015659; Expressed in metanephros cortex and 102 other tissues.
DR GO; GO:0097361; C:CIA complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0071817; C:MMXD complex; ISS:UniProtKB.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03037; ciao1; 1.
DR InterPro; IPR028608; CIAO1/Cia1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19920; PTHR19920; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Chromosome partition; Cytoplasm; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..339
FT /note="Probable cytosolic iron-sulfur protein assembly
FT protein CIAO1"
FT /id="PRO_0000244452"
FT REPEAT 14..53
FT /note="WD 1"
FT REPEAT 59..98
FT /note="WD 2"
FT REPEAT 103..142
FT /note="WD 3"
FT REPEAT 148..187
FT /note="WD 4"
FT REPEAT 192..231
FT /note="WD 5"
FT REPEAT 250..289
FT /note="WD 6"
FT REPEAT 301..339
FT /note="WD 7"
FT MOTIF 176..178
FT /note="LYR motif; required for interaction with HSC20"
FT /evidence="ECO:0000250|UniProtKB:O76071"
SQ SEQUENCE 339 AA; 37773 MW; 939AAE34C8E82116 CRC64;
MKDSLVLLSR ILAHPDSRCW FLAWNPAGTL LASCGGDRSV RIWGREGDSW ICKSVLCEGH
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NEDDFECVTT LEGHENEVKS VAWAPSGNLL
ATCSRDKSVW VWEVDEEDEY ECVSVLNSHT QDVKHVVWHP SQELLASASY DDTVKLYREE
EDDWVCCATL EGHESTVWSL AFDPSGQRLA SCSDDRTVRI WRQYLPGNEQ GVACSGSEAS
WKCVCTLSGF HSRTIYDVAW CQLTGTLATA CGDDAIRVFE EDPGSDPQQP TFSLTAHVPQ
AHSQDVNCVA WNPKERGLLA SCSDDGELAF WKYQPSEGI