ID   CIAO1_CAEEL             Reviewed;         337 AA.
AC   Q9XW12;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 2.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog {ECO:0000255|HAMAP-Rule:MF_03037};
GN   ORFNames=Y18D10A.9;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- INTERACTION:
CC       Q9XW12; O62252: F45G2.10; NbExp=3; IntAct=EBI-367932, EBI-367937;
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; AL034393; CAA22322.2; -; Genomic_DNA.
DR   PIR; T26531; T26531.
DR   RefSeq; NP_493247.2; NM_060846.4.
DR   AlphaFoldDB; Q9XW12; -.
DR   SMR; Q9XW12; -.
DR   BioGRID; 38549; 1.
DR   IntAct; Q9XW12; 1.
DR   STRING; 6239.Y18D10A.9; -.
DR   EPD; Q9XW12; -.
DR   PaxDb; Q9XW12; -.
DR   PeptideAtlas; Q9XW12; -.
DR   EnsemblMetazoa; Y18D10A.9.1; Y18D10A.9.1; WBGene00012479.
DR   GeneID; 173152; -.
DR   KEGG; cel:CELE_Y18D10A.9; -.
DR   UCSC; Y18D10A.9; c. elegans.
DR   CTD; 173152; -.
DR   WormBase; Y18D10A.9; CE34506; WBGene00012479; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   GeneTree; ENSGT00940000158670; -.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; Q9XW12; -.
DR   OMA; AIWSKSS; -.
DR   OrthoDB; 793298at2759; -.
DR   PhylomeDB; Q9XW12; -.
DR   PRO; PR:Q9XW12; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00012479; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..337
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein CIAO1 homolog"
FT                   /id="PRO_0000382479"
FT   REPEAT          15..54
FT                   /note="WD 1"
FT   REPEAT          65..104
FT                   /note="WD 2"
FT   REPEAT          109..148
FT                   /note="WD 3"
FT   REPEAT          154..193
FT                   /note="WD 4"
FT   REPEAT          199..238
FT                   /note="WD 5"
FT   REPEAT          253..292
FT                   /note="WD 6"
FT   REPEAT          301..337
FT                   /note="WD 7"
SQ   SEQUENCE   337 AA;  38190 MW;  3BB0D8BBB9CBEDB0 CRC64;
     MLRQIGEFYH QGEKDDTSRV WMTCWHHGGR ILASCGDDKA VRVWSLVGEP DSKMRLECRT
     TLDDSHTRAV RSVAFSNDGK CLVSASFDAS VVVYQQEDGE FAEVNKLEGH ESEVKCAVFS
     KSDEFLATCS RDKSVWFWQQ DEDEDFSVSS ILQPHTQDVK QVAWHPTEDL LVSCSYDSSI
     RFYRFDGEDW VTQQKIDGCH VGTVWSIAFD TEGHRLVTVG EDHCIQLFVR ENIGSKSADQ
     DTWKSVARYD VENTRWPLYS VAWNSTNDVI ATGGGDCKIR LFKISSTPES PVIEHLGVVG
     RHELDVNHVA WNPNPKFSNL LTSASDDGTI RLWELEI