ID   CIAO1_CANAL             Reviewed;         383 AA.
AC   Q5AG86; A0A1D8PNI7;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   OrderedLocusNames=CAALFM_C502730CA; ORFNames=CaO19.11769, CaO19.4293;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBUNIT: Interacts with NAR1. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03037}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03037}. Note=Preferentially
CC       localized to the nucleus. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; CP017627; AOW29698.1; -; Genomic_DNA.
DR   RefSeq; XP_720601.2; XM_715508.2.
DR   AlphaFoldDB; Q5AG86; -.
DR   SMR; Q5AG86; -.
DR   STRING; 237561.Q5AG86; -.
DR   PRIDE; Q5AG86; -.
DR   GeneID; 3637738; -.
DR   KEGG; cal:CAALFM_C502730CA; -.
DR   CGD; CAL0000178398; orf19.11769.
DR   VEuPathDB; FungiDB:C5_02730C_A; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; Q5AG86; -.
DR   OrthoDB; 793298at2759; -.
DR   PRO; PR:Q5AG86; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:EnsemblFungi.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19920; PTHR19920; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..383
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein 1"
FT                   /id="PRO_0000382508"
FT   REPEAT          10..49
FT                   /note="WD 1"
FT   REPEAT          56..108
FT                   /note="WD 2"
FT   REPEAT          135..175
FT                   /note="WD 3"
FT   REPEAT          182..221
FT                   /note="WD 4"
FT   REPEAT          228..275
FT                   /note="WD 5"
FT   REPEAT          302..341
FT                   /note="WD 6"
FT   REPEAT          349..383
FT                   /note="WD 7"
SQ   SEQUENCE   383 AA;  42773 MW;  2FC8594AF80F1C23 CRC64;
     MVQLLHSIKA HNDKVWSVSV HPTLPIIATA STDKSTKLYK LSARQKFPLV AKLEDTHKRS
     IRSVAFKPPL GGADTPKSDF LDLPALAAGS FDSTISVWGI DEPDVEYDIE EVIANQKEIL
     TSPNNEWNLM AIIEGHENEV KAVDWNFQGQ YLASCSRDKT VWIWETDPET LEEFECVAVL
     NDHSQDVKNV SWHPSMNILA SSSYDDTIRI YQQDIAGDEW SCVGILNGHE GTVWCSKFES
     LKSPIADSSV LRLVSASDDL SVRIWVAKRE QEDDEQAKLE LPSSIRHTNE MVWEVESVLP
     SVHKYPVYSV AWSALTGKIA SAGSDGKIVV YSETEKGKWV IDSIHEGAHG VHEINCVIWA
     QLDDENEILV SAGDDGYVNL WKI